ArticleJapanese journal of cancer research : Gann2000
Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium.
Article in Japanese journal of cancer research : Gann, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Selecting Optimal Housekeeping Genes for RT-qPCR in Endometrial Cancer Studies: A Narrative Review.International journal of molecular sciences · 2025Review
- Article
- Review
- The Co-Expression of Estrogen Receptors ERα, ERβ, and GPER in Endometrial Cancer.International journal of molecular sciences · 2023Article
- Unsupervised Clustering of Immunohistochemical Markers to Define High-Risk Endometrial Cancer.Pathology oncology research : POR · 2019Article
- Endometrial Carcinoma in a 26-Year-Old Patient with Bardet-Biedl Syndrome.Case reports in obstetrics and gynecology · 2018Article
- Role of metformin in inhibiting estrogen-induced proliferation and regulating ERα and ERβ expression in human endometrial cancer cells.Oncology letters · 2017Article
- The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers.Frontiers in pharmacology · 2017Review
- The Regulation of Steroid Action by Sulfation and Desulfation.Endocrine reviews · 2015Review
- Expression and clinical significance of FXYD3 in endometrial cancer.Oncology letters · 2014Article
- Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors.Journal of drug delivery · 2013Article
- Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli.Reproductive biology and endocrinology : RB&E · 2011Article
- The different roles of ER subtypes in cancer biology and therapy.Nature reviews. Cancer · 2011Review
- Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells.Oncogene · 2005Article
- Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors.Journal of the American Society for Mass Spectrometry · 2005Article
- Establishment and characterization of a new human cell line (EJ) derived from endometrial carcinoma.Human cell · 2002Article
- Distinct expression patterns of ER alpha and ER beta in normal human mammary gland.Journal of clinical pathology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To clarify changes in estrogen receptor (ER) alpha and ERbeta during endometrial tumorigenesis, 48 endometrial carcinomas (endometrioid type), as well as 40 samples of normal endometrial tissue, were investigated using a combination of reverse-transcription and polymerase chain reaction with Southern blot hybridization and western blot assays, and the results were compared with findings for progesterone receptor (PR) and pS2 mRNA status. In addition, 166 carcinomas were also examined for immunohistochemistry, along with 171 normal specimens. Relative amounts of ERalpha at both mRNA and protein levels were significantly greater than those for ERbeta in normal and malignant endometrial lesions. ERalpha mRNA showed a stepwise decrease from normal or grade (G) 1 through to G3 tumor lesions, in line with changes in the protein levels, in contrast to ERbeta mRNA or protein expression, which did not alter, suggesting a shift in the ratio of the two ER subtypes during endometrial tumorigenesis. PR mRNA expression was significantly correlated with ERalpha, but not ERbeta mRNA status. Although significantly higher expression of pS2 mRNA or protein was observed in carcinomas than in the normal cases, there was no apparent association with the ER status. The findings suggest that alteration in estrogen signaling pathways may occur during endometrial tumorigenesis, and provide evidence that ERalpha expression may play an important role in the regulation of PR, but not pS2 expression in normal and malignant endometrium.
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