ArticleGenetics2000
Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Interaction of Male Specific Lethal complex and genomic imbalance on global gene expression in Drosophila.Scientific reports · 2021Article
- Identification of Histone Modifications Reveals a Role of H2b Monoubiquitination in Transcriptional Regulation ofInternational journal of biological sciences · 2021Article
- RNA-induced initiation of transcriptional silencing (RITS) complex structure and function.RNA biology · 2019Review
- Facts and artifacts in studies of gene expression in aneuploids and sex chromosomes.Chromosoma · 2014Review
- Male X-linked genes in Drosophila melanogaster are compensated independently of the Male-Specific Lethal complex.Epigenetics & chromatin · 2013Article
- Dosage compensation and inverse effects in triple X metafemales of Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Male-specific lethal complex in Drosophila counteracts histone acetylation and does not mediate dosage compensation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Autoregulation of the Drosophila Noncoding roX1 RNA Gene.PLoS genetics · 2012Article
- X chromosomal regulation in flies: when less is more.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Interaction study of the male specific lethal (MSL) complex and trans-acting dosage effects in metafemales of Drosophila melanogaster.Cytogenetic and genome research · 2009Article
- Regulatory RNAs and chromatin modification in dosage compensation: a continuous path from flies to humans?Reproductive biology and endocrinology : RB&E · 2008Review
- roX RNAs are required for increased expression of X-linked genes in Drosophila melanogaster males.Genetics · 2006Article
- Misregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids.Genetics · 2006Article
- The Drosophila MSL complex activates the transcription of target genes.Genes & development · 2005Article
- The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.Molecular and cellular biology · 2005Article
- Gene expression analysis of the function of the male-specific lethal complex in Drosophila.Genetics · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of sex determination mechanisms is often accompanied by reduction in dosage of genes on a whole chromosome. Under these circumstances, negatively acting regulatory genes would tend to double the expression of the genome, which produces compensation of the single-sex chromosome and increases autosomal gene expression. Previous work has suggested that to reduce the autosomal expression to the female level, these dosage effects are modified by a chromatin complex specific to males, which sequesters a histone acetylase to the X. The reduced autosomal histone 4 lysine 16 (H4Lys16) acetylation results in lowered autosomal expression, while the higher acetylation on the X is mitigated by the male-specific lethal complex, preventing overexpression. In this report, we examine how mutations in the principal sex determination gene, Sex lethal (Sxl), impact the H4 acetylation and gene expression on both the X and autosomes. When Sxl expression is missing in females, we find that the sequestration occurs concordantly with reductions in autosomal H4Lys16 acetylation and gene expression on the whole. When Sxl is ectopically expressed in Sxl(M) mutant males, the sequestration is disrupted, leading to an increase in autosomal H4Lys16 acetylation and overall gene expression. In both cases we find relatively little effect upon X chromosomal gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.