ArticleGenetics2000
Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 69 citations in OpenAlex.
- Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment.Nature structural & molecular biology · 2025Article
- miR-137 targets Myc to regulate growth during eye development.Development (Cambridge, England) · 2025Article
- Cell Cycle Regulation by NF-YC inInternational journal of molecular sciences · 2023Article
- The value of EYA1/3/4 in clear cell renal cell carcinoma: a study from multiple databases.Scientific reports · 2023Article
- A recurrent missense variant in EYA3 gene is associated with oculo-auriculo-vertebral spectrum.Human genetics · 2021Article
- An E3 ubiquitin ligase, cullin-4 regulates retinal differentiation in Drosophila eye.Genesis (New York, N.Y. : 2000) · 2020Article
- Two modes of transvection at the eyes absent gene of Drosophila demonstrate plasticity in transcriptional regulatory interactions in cis and in trans.PLoS genetics · 2019Article
- Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression.Nature communications · 2018Article
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- Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development.Scientific reports · 2016Article
- Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation.PLoS genetics · 2013Article
- The Eyes Absent proteins in development and disease.Cellular and molecular life sciences : CMLS · 2013Review
- Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.Nature structural & molecular biology · 2013Article
- Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival.PloS one · 2013Article
- Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6.RNA (New York, N.Y.) · 2012Article
- Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.PloS one · 2012Article
- EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis.Biology of the cell · 2010Article
- Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- The retinal determination gene eyes absent is regulated by the EGF receptor pathway throughout development in Drosophila.Genetics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The eyes absent (eya) gene is critical to eye formation in Drosophila; upon loss of eya function, eye progenitor cells die by programmed cell death. Moreover, ectopic eya expression directs eye formation, and eya functionally synergizes in vivo and physically interacts in vitro with two other genes of eye development, sine oculis and dachshund. The Eya protein sequence, while highly conserved to vertebrates, is novel. To define amino acids critical to the function of the Eya protein, we have sequenced eya alleles. These mutations have revealed that loss of the entire Eya Domain is null for eya activity, but that alleles with truncations within the Eya Domain display partial function. We then extended the molecular genetic analysis to interactions within the Eya Domain. This analysis has revealed regions of special importance to interaction with Sine Oculis or Dachshund. Select eya missense mutations within the Eya Domain diminished the interactions with Sine Oculis or Dachshund. Taken together, these data suggest that the conserved Eya Domain is critical for eya activity and may have functional subregions within it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.