ArticleGenetics2000
Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Pathways of rDNA copy number homeostasis in Schizosaccharomyces pombe.G3 (Bethesda, Md.) · 2026Article
- Characterization of the Swi6/HP1 binding motif in its partner protein reveals the basis for the functional divergence of the HP1 family proteins in fission yeast.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- ThemicroPublication biology · 2025Article
- Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions.Nucleic acids research · 2024Article
- Article
- Coordination of histone chaperones for parental histone segregation and epigenetic inheritance.Genes & development · 2024Article
- Structural insights into the binding mechanism of Clr4 methyltransferase to H3K9 methylated nucleosome.Scientific reports · 2024Article
- Tracking live-cell single-molecule dynamics enables measurements of heterochromatinassociated protein-protein interactions.bioRxiv : the preprint server for biology · 2023Article
- Impact of 1,6-hexanediol on Schizosaccharomyces pombe genome stability.G3 (Bethesda, Md.) · 2023Article
- Review
- Functions of HP1 proteins in transcriptional regulation.Epigenetics & chromatin · 2022Review
- Facultative heterochromatin formation in rDNA is essential for cell survival during nutritional starvation.Nucleic acids research · 2022Article
- Establishment of heterochromatin in domain-size-dependent bursts.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Insights into HP1a-Chromatin Interactions.Cells · 2020Review
- RNA-induced initiation of transcriptional silencing (RITS) complex structure and function.RNA biology · 2019Review
- Article
- Regulation of centromeric heterochromatin in the cell cycle by phosphorylation of histone H3 tyrosine 41.Current genetics · 2019Review
- An RNA aptamer to HP1/Swi6 facilitates heterochromatin formation at an ectopic locus in S.pombe.RNA biology · 2019Article
- Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.PLoS genetics · 2019Article
- Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK inGenetics · 2019Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription is repressed in regions of the fission yeast genome close to centromeres, telomeres, or the silent mating-type cassettes mat2-P and mat3-M. The repression involves the chromo-domain proteins Swi6 and Clr4. We report that two other chromo-domain proteins, Chp1 and Chp2, are also important for these position effects. Chp1 showed a specificity for centromeric regions. Its essentiality for the transcriptional repression of centromeric markers correlates with its importance for chromosome stability. Chp2 appeared more pleiotropic. Its effects on centromeric silencing were less pronounced than those of Chp1, and it participated in telomeric position effects and transcriptional silencing in the mating-type region. We also found that PolII-transcribed genes were repressed when placed in one of the Schizosaccharomyces pombe rDNA clusters, a situation analogous to that in the budding yeast Saccharomyces cerevisiae. Chp2, Swi6, Clr4, and, to a lesser extent, Chp1 participated in that repression.
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