ArticleAmerican journal of human genetics2000
Bayesian fine-scale mapping of disease loci, by hidden Markov models.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 88 citations in OpenAlex.
- Estimating Time to the Common Ancestor for a Beneficial Allele.Molecular biology and evolution · 2018Article
- High-resolution genetic mapping with pooled sequencing.BMC bioinformatics · 2012Article
- Article
- The limits of fine-scale mapping.Genetic epidemiology · 2009Article
- Association mapping of complex trait loci with context-dependent effects and unknown context variable.Genetics · 2006Article
- Multilocus association mapping using variable-length Markov chains.American journal of human genetics · 2006Article
- Association mapping with single-feature polymorphisms.Genetics · 2006Article
- Modeling haplotype block variation using Markov chains.Genetics · 2006Article
- Linkage disequilibrium interval mapping of quantitative trait loci.BMC genomics · 2006Article
- Detecting genome wide haplotype sharing using SNP or microsatellite haplotype data.Human genetics · 2006Article
- Fine mapping--19th century style.BMC genetics · 2005Article
- Article
- Article
- Fine-scale mapping of disease genes with multiple mutations via spatial clustering techniques.American journal of human genetics · 2003Article
- Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data.Genetics · 2003Article
- Genetic epidemiology, genetic maps and positional cloning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2003Review
- The extent of linkage disequilibrium and haplotype sharing around a polymorphic site.Genetics · 2003Article
- The impact of genomics on the study of natural variation in Arabidopsis.Plant physiology · 2003Article
- Fine mapping of complex trait genes combining pedigree and linkage disequilibrium information: a Bayesian unified framework.Genetics · 2003Article
- Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations.American journal of human genetics · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a new multilocus method for the fine-scale mapping of genes contributing to human diseases. The method is designed for use with multiple biallelic markers-in particular, single-nucleotide polymorphisms for which high-density genetic maps will soon be available. We model disease-marker association in a candidate region via a hidden Markov process and allow for correlation between linked marker loci. Using Markov-chain-Monte Carlo simulation methods, we obtain posterior distributions of model parameter estimates including disease-gene location and the age of the disease-predisposing mutation. In addition, we allow for heterogeneity in recombination rates, across the candidate region, to account for recombination hot and cold spots. We also obtain, for the ancestral marker haplotype, a posterior distribution that is unique to our method and that, unlike maximum-likelihood estimation, can properly account for uncertainty. We apply the method to data for cystic fibrosis and Huntington disease, for which mutations in disease genes have already been identified. The new method performs well compared with existing multi-locus mapping methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.