ArticleThe Journal of physiology2000
Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
136 citing papers in PubMed, 296 citations in OpenAlex.
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- Bioisostere-conjugated fluorescent probes for live-cell protein imaging without non-specific organelle accumulation.Chemical science · 2024Article
- CaPhysiological reviews · 2024Review
- Transcriptome and Proteome Profiling of Primary Human Gastric Interstitial Cells of Cajal Predicts Pacemaker Networks.Journal of neurogastroenterology and motility · 2023Article
- Effects of black garlic on the pacemaker potentials of interstitial cells of Cajal in murine small intestineAnimal cells and systems · 2022Article
- Ibogaine-Mediated ROS/Antioxidant Elevation in Isolated Rat Uterus Is β-Adrenergic Receptors and KAntioxidants (Basel, Switzerland) · 2021Article
- CaCell calcium · 2021Article
- Gastrointestinal Dysmotility Is a Significant Feature in 2 Siblings With a Novel Inositol 1,4,5-Triphosphate Receptor 1 (ACG case reports journal · 2021Article
- Bicarbonate ion transport by the electrogenic NaNeurogastroenterology and motility · 2021Article
- Uterine contractions in rodent models and humans.Acta physiologica (Oxford, England) · 2021Review
- Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.WIREs mechanisms of disease · 2021Review
- CaeLife · 2021Article
- Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Expression of the regulated isoform of the electrogenic NaAmerican journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Co‑expression network analysis identified specific miRNAs and genes in association with slow‑transit constipation.Molecular medicine reports · 2020Article
- Transient Receptor Potential Canonical 4 and 5 Channel Antagonist ML204 Depolarized Pacemaker Potentials of Interstitial Cells of Cajal.Journal of neurogastroenterology and motility · 2020Article
- Identification and classification of interstitial cells in the mouse renal pelvis.The Journal of physiology · 2020Article
- Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility.International journal of molecular sciences · 2020Review
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Pacemaker cells, known as interstitial cells of Cajal (ICC), generate electrical rhythmicity in the gastrointestinal tract. Pacemaker currents in ICC result from the activation of a voltage-independent, non-selective cation conductance, but the timing mechanism responsible for periodic activation of the pacemaker current is unknown. Previous studies suggest that pacemaking in ICC is dependent upon metabolic activity 1y1yand1 Ca2+ release from intracellular stores. We tested the hypothesis that mitochondrial Ca2+ handling may underlie the dependence of gastrointestinal pacemaking on oxidative metabolism. Pacemaker currents occurred spontaneously in cultured ICC and were associated with mitochondrial Ca2+ transients. Inhibition of the electrochemical gradient across the inner mitochondrial membrane blocked Ca2+ uptake and pacemaker currents in cultured ICC and blocked slow wave activity in intact gastrointestinal muscles from mouse, dog and guinea-pig. Pacemaker currents and rhythmic mitochondrial Ca2+ uptake in ICC were also blocked by inhibitors of IP3-dependent release of Ca2+ from the endoplasmic reticulum and by inhibitors of endoplasmic reticulum Ca2+ reuptake. Our data suggest that integrated Ca2+ handling by endoplasmic reticulum and mitochondria is a prerequisite of electrical pacemaking in the gastrointestinal tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.