ArticleJournal of clinical microbiology2000
Intestinal lesions associated with disseminated candidiasis in an experimental animal model.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- An experimental porcine model of invasive candidiasis.Intensive care medicine experimental · 2023Article
- Profuse diversity and acidogenicity of theJournal of oral microbiology · 2021Article
- Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.Oncotarget · 2016Article
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- Innocent until proven guilty: mechanisms and roles of Streptococcus-Candida interactions in oral health and disease.Molecular oral microbiology · 2014Review
- Article
- Hosting infection: experimental models to assay Candida virulence.International journal of microbiology · 2012Article
- Reactivity of (1→3)-β-d-glucan assay in bacterial bloodstream infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
- Immunosensing during colonization by Candida albicans: does it take a village to colonize the intestine?Trends in microbiology · 2011Article
- Candida species differ in their interactions with immature human gastrointestinal epithelial cells.Pediatric research · 2011Article
- The RIM101 signal transduction pathway regulates Candida albicans virulence during experimental keratomycosis.Investigative ophthalmology & visual science · 2010Article
- Article
- Self-regulation of Candida albicans population size during GI colonization.PLoS pathogens · 2007Article
- A glucose sensor in Candida albicans.Eukaryotic cell · 2006Article
- Effectiveness of bombesin and Saccharomyces boulardii against the translocation of Candida albicans in the digestive tract in immunosuppressed rats.Surgery today · 2005Article
- Characterization of Candida albicans colony morphological mutants and their hybrids by means of RAPD-PCR, isoenzyme analysis and pathogenicity analysis.Folia microbiologica · 2004Article
- Prospective evaluation of Candida species colonization in hospitalized cancer patients: impact on short-term survival in recipients of marrow transplantation and patients with hematological malignancies.Bone marrow transplantation · 2002Article
- Review
- A bovine lactoferricin-lactoferrampin-encodingGut microbesArticle
- A pig model of the human gastrointestinal tract.Gut microbesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In human patients, disseminated candidiasis, a life-threatening disease for immunocompromised patients, is often associated with intestinal lesions. In this study, we demonstrate that immunosuppressed gnotobiotic (IGB) piglets orally inoculated with wild-type Candida albicans developed extensive intestinal lesions and disseminated infection. Severe ulceration of the ileal mucosa was observed overlying regions of colonization and necrosis of the gut-associated lymphoid tissue. Despite the high susceptibility of IGB piglets to many microbial pathogens, an avirulent mutant strain of C. albicans failed to produce intestinal lesions and exhibited poor dissemination, demonstrating that these effects required virulent organisms. It is likely that in IGB piglets, as in human patients, intestinal lesions provide the mechanism for escape of C. albicans from the gastrointestinal tract. Multinucleated giant cells containing fungal organisms were observed within lymph nodes and lymphatic vessels, and as with other pathogens, such cells could provide a mechanism for dissemination of C. albicans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.