ArticleJournal of clinical microbiology2000
High rate of tetracycline resistance in Streptococcus pyogenes in Iran: an epidemiological study.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Prevalence and emm typing of multi-drug resistant Streptococcus pyogenes in tertiary care health settings.BMC microbiology · 2025Article
- Group AOman medical journal · 2021Review
- Antimicrobial resistance in beta-haemolytic streptococci in India: A four-year study.The Indian journal of medical research · 2018Article
- Molecular characterization and evaluation of the emerging antibiotic-resistant Streptococcus pyogenes from eastern India.BMC infectious diseases · 2016Article
- Antibiotic Susceptibility Evaluation of Group A Streptococcus Isolated from Children with Pharyngitis: A Study from Iran.Infection & chemotherapy · 2015Article
- Group A β-hemolytic Streptococcal Infection in Children and the Resultant Neuro-psychiatric Disorder; a Cross Sectional Study; Tehran, Iran.Basic and clinical neuroscience · 2015Article
- Antibiotic susceptibility of streptococcus pyogenes isolated from respiratory tract infections in dakar, senegal.Microbiology insights · 2013Article
- Molecular epidemiology, antimicrobial susceptibilities and resistance mechanisms of Streptococcus pyogenes isolates resistant to erythromycin and tetracycline in Spain (1994-2006).BMC microbiology · 2012Article
- Macrolide and tetracycline resistance and emm type distribution of Streptococcus pyogenes isolates recovered from Turkish patients.Microbial drug resistance (Larchmont, N.Y.) · 2010Article
- Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis.Clinical microbiology reviews · 2010Review
- Antibiotic resistant beta-hemolytic streptococci.Indian journal of pediatrics · 2007Article
- Antibacterial resistance.Indian journal of pediatrics · 2004Review
- Bacitracin-resistant clone of Streptococcus pyogenes isolated from pharyngitis patients in Belgium.Journal of clinical microbiology · 2003Article
- Unusual occurrence of M type 77, antibiotic-resistant group A streptococci in southern Sweden.Journal of clinical microbiology · 2001Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus pyogenes, a major human pathogen, is still considered susceptible to beta-lactams, but for other relevant antibiotics, highly variable resistance rates have been reported. Since no data were available from Iran, we tested 1,335 throat isolates from two different regions of the country for their antibiotic susceptibilities and, for comparison, a collection of 80 strains isolated from 1989 to 1991. Erythromycin resistance was uncommon (0.6%), whereas an overall high rate of tetracycline resistance was found, increasing between 1989-1991 and 1995-1997 from 23 to 42%. The tetracycline-resistant strains belonged to more than 10 different T types, the majority being types 4, 11, and B3264. By conventional M typing of 406 tetracycline-resistant isolates, more than 20 different M types were found. Approximately 50% of the strains were nontypeable by T agglutination as well as serological M typing; however, by genotyping by a combined PCR-capture-enzyme-linked immunosorbent assay, many of these strains were successfully emm typed. We conclude that the high rate of tetracycline resistance among Iranian S. pyogenes isolates is due to multiclonal dissemination of resistance within the streptococcal population rather than epidemic spread of single clones.
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