Trial reportArchives of disease in childhood2000
Lung deposition of aerosol--a comparison of different spacers.
Trial report in Archives of disease in childhood, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 58 citations in OpenAlex.
- Valved Holding Chambers in Young Children With Acute Wheezing: A Randomized Clinical Trial.JAMA pediatrics · 2026Trial
- Usefulness of Nonvalved Spacers for Administration of Inhaled Steroids in Young Children with Recurrent Wheezing and Risk Factors for Asthma.Canadian respiratory journal · 2018Trial
- Age dependent systemic exposure to inhaled salbutamol.British journal of clinical pharmacology · 2007Trial
- Randomized trial of spacers in asthma.Indian journal of pediatrics · 2007Trial
- Randomised controlled trial of the efficacy of a metered dose inhaler with bottle spacer for bronchodilator treatment in acute lower airway obstruction.Archives of disease in childhood · 2007Trial
- Effect of plastic spacer handling on salbutamol lung deposition in asthmatic children.British journal of clinical pharmacology · 2002Trial
- Efficacy of a home-made spacer with acute exacerbation of bronchial asthma: a randomized controlled trial.Indian journal of pediatrics · 2001Trial
- Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study.European journal of pediatrics · 2021Observational
- Comparison of pulmonary deposition of nebulizedJournal of veterinary internal medicine · 2021Article
- Mask Use with Spacers/Valved Holding Chambers and Metered Dose Inhalers among Children with Asthma.Annals of the American Thoracic Society · 2021Review
- A Rationale for Going Back to the Future: Use of Disposable Spacers for Pressurised Metered Dose Inhalers.Pulmonary medicine · 2015Review
- Use of inhaler devices in pediatric asthma.Paediatric drugs · 2003Review
- Antiasthmatic drug delivery in children.Paediatric drugs · 2002Review
- Leptin and metabolic hormones in infants of diabetic mothers.Archives of disease in childhood. Fetal and neonatal edition · 2000Article
- Clinical course of patients with major histocompatibility complex class II deficiency.Archives of disease in childhood · 2000Article
- Kawasaki disease complicated by renal artery stenosis.Archives of disease in childhood · 2000Article
- Idiopathic pulmonary fibrosis in infants: good prognosis with conservative management.Archives of disease in childhood · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate (1) aerosol lung deposition obtained from two small volume conventional spacers (Babyhaler and Aerochamber) and a home made spacer (modified 500 ml plastic cold drink bottle); (2) the effect of using a face mask or mouthpiece; and (3) the relation between age and pulmonary deposition.
methodsLung deposition of aerosolised technetium-99m DTPA inhaled via spacer was measured in 40 children aged 3-7 years with stable asthma. Each patient performed sequential randomly assigned inhalations using two spacers. Three studies were performed: Babyhaler compared to Aerochamber (with facemasks); Babyhaler with facemask compared to Babyhaler with mouthpiece; and Babyhaler with mouthpiece compared to a 500 ml bottle.
resultsMedian lung aerosol deposition from a Babyhaler and Aerochamber with masks were similar (25% v 21%, p = 0.9). Aerosol lung deposition from a Babyhaler with mask compared to a Babyhaler with mouthpiece was equivalent (26% v 26%, p = 0.5). Lung deposition was higher from a 500 ml bottle compared to a Babyhaler in both young (25% v 12.5%, p = 0.005) and older children (42% v 22.5%, p = 0.003). A notable reduction in pulmonary deposition occurred at 50 months of age.
conclusionA Babyhaler or Aerochamber produce equivalent lung deposition of aerosol. There is no difference in lung deposition when a mask or mouthpiece is used. A modified 500 ml plastic bottle produces greater pulmonary aerosol deposition than a conventional small volume spacer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.