Evidence map›Paper›PMID 10830137›Full record

ReviewInvestigational new drugs2000

Development of target-based antineoplastic agents.

W M Stadler, M J Ratain

Abstract readReview
PubMed Publisher
In one paragraph

Review in Investigational new drugs, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. New target-based agents involve new clinical trial designs.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2006
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

W M StadlerDepartment of Medicine, University of Chicago, IL 60637, USA.
M J Ratain

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The elucidation of multiple potential targets in cancer cells and the development of multiple target-based antineoplastic agents provide unique challenges in clinical trial design. Many of these agents are predicted to have cytostatic as opposed to cytotoxic effects and thus the traditional surrogate endpoint of radiologic tumor shrinkage may be inadequate. The ethical and safety issues of obtaining multiple tumor biopsies further complicate the assessment of appropriate target inhibition in patients. We discuss specific issues that need to be addressed during preclinical, phase I, II, and III testing of these agents. We propose clinical trial designs, including a randomized discontinuation design during phase II evaluation, that may be particularly useful for cytostatic antineoplastic agents.

Indexed as

Antineoplastic AgentsClinical Trials as TopicDrug DesignHumansNeoplasmsResearch DesignAntineoplastic Agents

Identifiers

PMID10830137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.