ArticleProceedings of the National Academy of Sciences of the United States of America2000
B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements.Blood cancer discovery · 2025Article
- Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion.Cell reports · 2024Article
- B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells.Immunological reviews · 2022Review
- A single donor is sufficient to produce a highly functional in vitro antibody library.Communications biology · 2021Article
- Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.Nature immunology · 2020Article
- Active PI3K abrogates central tolerance in high-avidity autoreactive B cells.The Journal of experimental medicine · 2019Article
- Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance.Frontiers in immunology · 2018Article
- IgH isotype-specific B cell receptor expression influences B cell fate.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Receptor editing and genetic variability in human autoreactive B cells.The Journal of experimental medicine · 2016Article
- Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts.Diabetes · 2013Article
- Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- B cell receptor editing in tolerance and autoimmunity.Annals of the New York Academy of Sciences · 2011Review
- BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- B-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.Transplantation reviews (Orlando, Fla.) · 2010Review
- Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation.The Journal of experimental medicine · 2010Article
- B-cell tolerance in transplantation: is repertoire remodeling the answer?Expert review of clinical immunology · 2009Article
- A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.The Journal of experimental medicine · 2009Article
- A role for interferon regulatory factor 4 in receptor editing.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
During B lymphocyte development, antibody genes are assembled by DNA recombination. Successful cell surface expression of IgM promotes developmental progression. However, when antigen receptors bind autoantigen, development is blocked and ongoing antibody gene recombination occurs, which often alters antibody specificity in a process called receptor editing. We demonstrate here a significant role of developmental block and receptor editing in B cell receptor quality control. During development a functional, non-self-reactive receptor undergoes receptor editing if its expression is below a certain threshold. Doubling the receptor gene dose promotes development in the absence of autoantigen, but allows editing when autoantigen is present. Thus, both underexpressed and harmful B cell receptors can undergo correction by receptor editing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.