ArticleProceedings of the National Academy of Sciences of the United States of America2000
Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 202 citations in OpenAlex.
- Cardiac unloading models for myocardial reverse remodeling.Basic research in cardiology · 2026Review
- Distinct morphometric features of cardiomyocytes isolated from mouse hypertrophy models: An ImageJ analysis combined with machine learning algorithms.Physiological reports · 2025Article
- Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus specific.American journal of physiology. Heart and circulatory physiology · 2022Article
- Reverse Remodeling With Left Ventricular Assist Devices.Circulation research · 2021Review
- Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.Circulation · 2019Article
- Olmesartan attenuates pressure-overload- or post-infarction-induced cardiac remodeling in mice.Oncotarget · 2018Article
- Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure.Circulation. Heart failure · 2018Article
- Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress.Pflugers Archiv : European journal of physiology · 2017Article
- Three TF Co-expression Modules Regulate Pressure-Overload Cardiac Hypertrophy in Male Mice.Scientific reports · 2017Article
- Biomarkers in cardiovascular disease: Statistical assessment and section on key novel heart failure biomarkers.Trends in cardiovascular medicine · 2017Review
- Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility.Journal of cardiovascular translational research · 2016Review
- Functional significance of the discordance between transcriptional profile and left ventricular structure/function during reverse remodeling.JCI insight · 2016Article
- Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress.Journal of translational medicine · 2016Article
- Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin-dependent protein kinase II.British journal of pharmacology · 2015Article
- Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells.Cardiovascular research · 2014Article
- Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I.FEBS open bio · 2013Article
- Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart.PloS one · 2013Article
- Recovery from decompensated heart failure is associated with a distinct, phase-dependent gene expression profile.The Journal of surgical research · 2012Article
- Propofol improves recovery of the isolated working hypertrophic heart from ischaemia-reperfusion.Pflugers Archiv : European journal of physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Although cardiac hypertrophy has been the subject of intensive investigation, regression of hypertrophy has been significantly less studied, precluding large-scale analysis of the relationship between these processes. In the present study, using pharmacological models of cardiac hypertrophy in mice, expression profiling was performed with fragments of more than 4,000 genes to characterize and contrast expression changes during induction and regression of hypertrophy. Administration of angiotensin II and isoproterenol by osmotic minipump produced increases in heart weight (15 and 45%, respectively) that returned to preinduction size after drug withdrawal. From multiple expression analyses of left ventricular RNA isolated at daily time-points during cardiac hypertrophy and regression, we identified sets of genes whose expression was altered at specific stages of this process. While confirming the participation of 25 genes or pathways previously shown to be altered by hypertrophy, a larger set of 30 genes was identified whose expression had not previously been associated with cardiac hypertrophy or regression. Of the 55 genes that showed reproducible changes during the time course of induction and regression, 32 genes were altered only during induction, and 8 were altered only during regression. This study identified both known and novel genes whose expression is affected at different stages of cardiac hypertrophy and regression and demonstrates that cardiac remodeling during regression utilizes a set of genes that are distinct from those used during induction of hypertrophy.
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