ArticleOncogene2000
Dominant negative Met reduces tumorigenicity-metastasis and increases tubule formation in mammary cells.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Met is required for oligodendrocyte progenitor cell migration in Danio rerio.G3 (Bethesda, Md.) · 2021Article
- For robust big data analyses: a collection of 150 important pro-metastatic genes.Chinese journal of cancer · 2017Review
- Article
- Live time-lapse dataset of in vitro wound healing experiments.GigaScience · 2015Article
- Propagating waves of directionality and coordination orchestrate collective cell migration.PLoS computational biology · 2014Article
- Article
- Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer.Medical oncology (Northwood, London, England) · 2014Article
- Interplay Between HGF/SF-Met-Ras Signaling, Tumor Metabolism and Blood Flow as a Potential Target for Breast Cancer Therapy.Oncoscience · 2014Article
- Association of activated c-Met with NRAS-mutated human melanomas.International journal of cancer · 2012Article
- Secrets of tubule engineering by epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Emergence of HGF/SF-induced coordinated cellular motility.PloS one · 2012Article
- Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma.Neoplasia (New York, N.Y.) · 2006Article
- HGF/SF increases tumor blood volume: a novel tool for the in vivo functional molecular imaging of Met.Neoplasia (New York, N.Y.) · 2006Article
- Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Tumour-stromal interactions. Transforming growth factor-beta isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis.Breast cancer research : BCR · 2001Review
- Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of the Met tyrosine kinase growth factor receptor by its ligand HGF/SF has been shown to increase in vitro invasiveness in epithelial cell lines. To study the effect of Met-HGF/SF signaling in breast cancer cells, we transfected met, hgf/sf and dominant negative (DN) forms of met into the poorly differentiated metastatic murine mammary adenocarcinoma cell line DA3. These cells express moderate levels of endogenous Met, which is rapidly phosphorylated in response to HGF/SF treatment. Met+hgf/sf transfection results in significantly increased tumorigenic and metastatic activity in vivo accompanied by reduced tubule formation. DA3 cells transfected with DN forms of Met (DN-DA3) exhibit reduced Met phosphorylation following exposure to HGF/SF. Furthermore, as compared to the parental cells, the DN-DA3 cells exhibit diminished in vitro scattering and invasiveness, while in vivo they display greatly reduced tumorigenicity and spontaneous metastasis. Tumors emanating from DN-DA3 cells injected to BALB/C mice are highly differentiated and display extensive tubule formation. These results suggest that Met-HGF/SF signaling is a determining factor in the delicate balance between differentiation/tubule formation and tumorigenicity-metastasis. Oncogene (2000) 19, 2386 - 2397
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.