ArticleBiophysical journal2000
A membrane bending model of outer hair cell electromotility.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 147 citations in OpenAlex.
- Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice.The Journal of biological chemistry · 2026Article
- Flexoelectricity and the fluctuations of (active) living cells: Implications for energy harvesting, ion transport, and neuronal activity.PNAS nexus · 2025Article
- Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research.Bioengineering (Basel, Switzerland) · 2025Review
- A minimal physics-based model for musical perception.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Plasmonic imaging of subcellular electromechanical deformation in mammalian cells.Journal of biomedical optics · 2019Article
- 3D Ultrastructure of the Cochlear Outer Hair Cell Lateral Wall Revealed By Electron Tomography.Frontiers in cellular neuroscience · 2019Article
- Diflunisal inhibits prestin by chloride-dependent mechanism.PloS one · 2017Article
- Actuation of flexoelectric membranes in viscoelastic fluids with applications to outer hair cells.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2014Article
- Chloride and salicylate influence prestin-dependent specific membrane capacitance: support for the area motor model.The Journal of biological chemistry · 2014Article
- The capacitance and electromechanical coupling of lipid membranes close to transitions: the effect of electrostriction.Biophysical journal · 2012Article
- Cell membrane tethers generate mechanical force in response to electrical stimulation.Biophysical journal · 2010Article
- The remarkable cochlear amplifier.Hearing research · 2010Article
- WITHDRAWN: Membrane-based amplification in hearing.Hearing research · 2009Article
- Lipid lateral mobility in cochlear outer hair cells: regional differences and regulation by cholesterol.Journal of the Association for Research in Otolaryngology : JARO · 2009Article
- Optical coherence tomography phase measurement of transient changes in squid giant axons during activity.The Journal of membrane biology · 2009Article
- Power efficiency of outer hair cell somatic electromotility.PLoS computational biology · 2009Article
- Electrohydrodynamic model of vesicle deformation in alternating electric fields.Biophysical journal · 2009Article
- Hair cell bundles: flexoelectric motors of the inner ear.PloS one · 2009Article
- Amphipath-induced nanoscale changes in outer hair cell plasma membrane curvature.Biophysical journal · 2009Article
- Piezo- and Flexoelectric Membrane Materials Underlie Fast Biological Motors in the Ear.Materials Research Society symposia proceedings. Materials Research Society · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We propose a new mechanism for outer hair cell electromotility based on electrically induced localized changes in the curvature of the plasma membrane (flexoelectricity). Electromechanical coupling in the cell's lateral wall is modeled in terms of linear constitutive equations for a flexoelectric membrane and then extended to nonlinear coupling based on the Langevin function. The Langevin function, which describes the fraction of dipoles aligned with an applied electric field, is shown to be capable of predicting the electromotility voltage displacement function. We calculate the electrical and mechanical contributions to the force balance and show that the model is consistent with experimentally measured values for electromechanical properties. The model rationalizes several experimental observations associated with outer hair cell electromotility and provides for constant surface area of the plasma membrane. The model accounts for the isometric force generated by the cell and explains the observation that the disruption of spectrin by diamide reduces force generation in the cell. We discuss the relation of this mechanism to other proposed models of outer hair cell electromotility. Our analysis suggests that rotation of membrane dipoles and the accompanying mechanical deformation may be the molecular mechanism of electromotility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.