ArticleBiophysical journal2000
Effects of mobile buffers on facilitation: experimental and computational studies.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 97 citations in OpenAlex.
- Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:CaeLife · 2020Article
- New insights into short-term synaptic facilitation at the frog neuromuscular junction.Journal of neurophysiology · 2015Article
- Calcium, calpain, and calcineurin in low-frequency depression of transmitter release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Protein kinase C acts as a molecular detector of firing patterns to mediate sensory gating in Aplysia.Nature neuroscience · 2012Article
- The diverse functions of short-term plasticity components in synaptic computations.Communicative & integrative biology · 2011Article
- Short-term facilitation modulates size and timing of the synaptic response at the inner hair cell ribbon synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Short-term forms of presynaptic plasticity.Current opinion in neurobiology · 2011Review
- Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization.Nature neuroscience · 2011Article
- Regulation of exocytic mode in hippocampal neurons by intra-bouton calcium concentration.The Journal of physiology · 2010Article
- Numerical analysis of Ca2+ signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulum.PLoS computational biology · 2010Article
- Interaction between facilitation and depression at a large CNS synapse reveals mechanisms of short-term plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Mechanisms underlying short-term modulation of transmitter release by presynaptic depolarization.The Journal of physiology · 2009Article
- Article
- A limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held.The Journal of physiology · 2008Article
- Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers.Journal of computational neuroscience · 2008Article
- Effects of increasing Ca2+ channel-vesicle separation on facilitation at the crayfish inhibitory neuromuscular junction.Neuroscience · 2008Article
- Increased Ca2+ influx through Na+/Ca2+ exchanger during long-term facilitation at crayfish neuromuscular junctions.The Journal of physiology · 2007Article
- Neurosteroid-induced enhancement of short-term facilitation involves a component downstream from presynaptic calcium in hippocampal slices.The Journal of physiology · 2006Article
- Calcium sensitivity of neurotransmitter release differs at phasic and tonic synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Local signaling with molecular diffusion as a decoder of Ca2+ signals in synaptic plasticity.Molecular systems biology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Facilitation is an important form of short-term plasticity that occurs in most synapses. At crayfish neuromuscular junctions, basal transmission and facilitation were significantly reduced after presynaptic introduction of "fast" high-affinity calcium buffers, and the decay of facilitation was accelerated. The existence of residual calcium during facilitation was also demonstrated. Computational modeling of three-dimensional buffered Ca(2+) diffusion and binding to secretory and facilitation targets suggest that the facilitation site is located away from a secretory trigger mediating exocytosis; otherwise, the facilitation site would be saturated by each action potential. Our simulations account for many characteristics of facilitation and effects of exogenous buffer, and suggest that facilitation is caused by residual calcium gaining access to a site distinct from the secretory trigger through restricted diffusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.