ArticleEmerging infectious diseases
Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.
Article in Emerging infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 241 citations in OpenAlex.
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- The effect of COVID-19 on the frequency of Pneumocystis jirovecii pneumonia: a monocentric, retrospective, and observational study.BMC infectious diseases · 2023Observational
- The conventional diagnosis challenge: Real-time PCR and nested PCR correlation with the scoring system for individuals at high-risk of Pneumocystis jirovecii pneumonia.Biomedica : revista del Instituto Nacional de Salud · 2023Article
- Apparent Absence of Selective Pressure on Pneumocystis jirovecii Organisms in Patients with Prior Methotrexate Exposure.Antimicrobial agents and chemotherapy · 2022Article
- Genetic Polymorphisms ofPolish journal of microbiology · 2022Article
- Update on Dihydropteroate Synthase (DHPS) Mutations inJournal of fungi (Basel, Switzerland) · 2021Review
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- Consensus Multilocus Sequence Typing Scheme forJournal of fungi (Basel, Switzerland) · 2020Review
- Pneumocystis primary infection in infancy: Additional French data and review of the literature.Medical mycology · 2020Article
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- Molecular diagnosis and genotyping ofCurrent medical mycology · 2019Article
- Genetic polymorphisms associated with treatment failure and mortality in pediatric Pneumocystosis.Scientific reports · 2019Article
- Prevalence and genotyping of Pneumocystis jirovecii in renal transplant recipients-preliminary report.Parasitology research · 2019Article
- Pneumocystis jirovecii and Cystic Fibrosis in Brittany, France.Mycopathologia · 2018Article
- Circulating genotypes of Pneumocystis jirovecii and its clinical correlation in patients from a single tertiary center in India.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Low prevalence of DHFR and DHPS mutations in Pneumocystis jirovecii strains obtained from a German cohort.Infection · 2017Article
- High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy.Antimicrobial agents and chemotherapy · 2017Article
- Review
6 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accounting for 17.8% of cases, were associated with primary PCP. Genotype frequency distribution patterns varied by patients' place of diagnosis but not by place of birth. Genetic variation at the two loci suggests three probable characteristics of transmission: that most cases of PCP do not result from infections acquired early in life, that infections are actively acquired from a relatively common source (humans or the environment), and that humans, while not necessarily involved in direct infection of other humans, are nevertheless important in the transmission cycle of P. carinii f. sp. hominis.
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