ArticleJournal of pharmacokinetics and biopharmaceutics1999
The anomalous pharmacokinetics of amiodarone explained by nonexponential tissue trapping.
Article in Journal of pharmacokinetics and biopharmaceutics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of the gamma-Pareto convolution with conventional methods of characterising metformin pharmacokinetics in dogs.Journal of pharmacokinetics and pharmacodynamics · 2020Pooled it
- CMINNs: Compartment model informed neural networks - Unlocking drug dynamics.Computers in biology and medicine · 2025Article
- A physiologically-based pharmacokinetic modeling approach for dosing amiodarone in children on ECMO.CPT: pharmacometrics & systems pharmacology · 2024Article
- Post-operative atrial fibrillation after cardiac surgery: Challenges throughout the patient journey.Frontiers in cardiovascular medicine · 2023Review
- A series acceleration algorithm for the gamma-Pareto (type I) convolution and related functions of interest for pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- Osteoporosis treatment with risedronate: a population pharmacokinetic model for the description of its absorption and low plasma levels.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Tailored Pharmacokinetic model to predict drug trapping in long-term anesthesia.Journal of advanced research · 2021Article
- Diffusion through skin in the light of a fractional derivative approach: progress and challenges.Journal of pharmacokinetics and pharmacodynamics · 2021Review
- Pharmacokinetics and biodistribution of a collagen-targeted peptide amphiphile for cardiovascular applications.Pharmacology research & perspectives · 2020Article
- A theoretical mathematical model for assessing diclofenac release from chitosan-based formulations.Drug delivery · 2020Article
- Fractional calculus in pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2018Article
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.Toxicology letters · 2016Article
- Exponential tails of drug disposition curves: reality or appearance?Journal of pharmacokinetics and pharmacodynamics · 2014Article
- How to avoid unbounded drug accumulation with fractional pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2013Article
- Fractional kinetics in multi-compartmental systems.Journal of pharmacokinetics and pharmacodynamics · 2010Article
- A commentary on fractionalization of multi-compartmental models.Journal of pharmacokinetics and pharmacodynamics · 2010Article
- Amiodarone concentrations in plasma and fat tissue during chronic treatment and related toxicity.British journal of clinical pharmacology · 2009Article
- Fractional kinetics in drug absorption and disposition processes.Journal of pharmacokinetics and pharmacodynamics · 2009Article
- Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts.The AAPS journal · 2007Review
- Multivariate statistics of disposition pharmacokinetic parameters for structurally unrelated drugs used in therapeutics.Pharmaceutical research · 2002Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional pharmacokinetic (PK) concepts fail to describe the long-term pharmacokinetics of the extremely cationic amphiphilic drug amiodarone. A nonclassical model based on the phenomenon of trapping at tissue binding sites with very long release times is presented, which implies that a volume of distribution and a steady-state level cannot be defined. In agreement with clinical PK data available in the literature, the model well describes not only single-dose disposition curves but also the persistently increasing plasma concentration-time curve during long-term treatment (up to 5 years) and the washout curve following cessation of therapy. The novel aspect is a long-tailed tissue residence time distribution which is incorporated into a recirculatory model leaving the initial distribution process and the clearance concept unchanged. The underlying theoretical approach, which is known as "strange or anomalous" kinetics in physical sciences, and the fractal scaling property of the model may enhance our understanding of the PK of extremely hydrophobic xenobiotics.
Indexed as
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10826129What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.