ArticleAmerican journal of human genetics2000
A test for linkage and association in general pedigrees: the pedigree disequilibrium test.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 251 papers, 2 of them syntheses that pooled it.
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Who cites it
251 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.Molecular psychiatry · 2005Trial
- Analysis of the RELN gene as a genetic risk factor for autism.Molecular psychiatry · 2005Trial
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- Snowball Effect of User Participation in Online Environmental Communities: Elaboration Likelihood under Social Influence.International journal of environmental research and public health · 2019Article
- A comparison of popular TDT-generalizations for family-based association analysis.Genetic epidemiology · 2019Article
- Statistical Methods and Software for Substance Use and Dependence Genetic Research.Current genomics · 2019Review
- A Family-Based Rare Haplotype Association Method for Quantitative Traits.Human heredity · 2018Article
- Generalized disequilibrium test for association in qualitative traits incorporating imprinting effects based on extended pedigrees.BMC genetics · 2017Article
- Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease.Molecular neurobiology · 2017Article
- The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data.American journal of human genetics · 2017Article
- A Pragmatic Test for Detecting Association between a Dichotomous Trait and the Genotypes of Affected Families, Controls and Independent Cases.Frontiers in genetics · 2017Article
- Genetic influences on adolescent behavior.Neuroscience and biobehavioral reviews · 2016Review
- The role of ASTN2 variants in childhood and adult ADHD, comorbid disorders and associated personality traits.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Testing Allele Transmission of an SNP Set Using a Family-Based Generalized Genetic Random Field Method.Genetic epidemiology · 2016Article
191 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Family-based tests of linkage disequilibrium typically are based on nuclear-family data including affected individuals and their parents or their unaffected siblings. A limitation of such tests is that they generally are not valid tests of association when data from related nuclear families from larger pedigrees are used. Standard methods require selection of a single nuclear family from any extended pedigrees when testing for linkage disequilibrium. Often data are available for larger pedigrees, and it would be desirable to have a valid test of linkage disequilibrium that can use all potentially informative data. In this study, we present the pedigree disequilibrium test (PDT) for analysis of linkage disequilibrium in general pedigrees. The PDT can use data from related nuclear families from extended pedigrees and is valid even when there is population substructure. Using computer simulations, we demonstrated validity of the test when the asymptotic distribution is used to assess the significance, and examined statistical power. Power simulations demonstrate that, when extended pedigree data are available, substantial gains in power can be attained by use of the PDT rather than existing methods that use only a subset of the data. Furthermore, the PDT remains more powerful even when there is misclassification of unaffected individuals. Our simulations suggest that there may be advantages to using the PDT even if the data consist of independent families without extended family information. Thus, the PDT provides a general test of linkage disequilibrium that can be widely applied to different data structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.