ArticleMolecular and cellular biology2000
Novel mechanism of steroid action in skin through glucocorticoid receptor monomers.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Is steroids therapy effective in treating phimosis? A meta-analysis.International urology and nephrology · 2016Pooled it
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- A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms.International journal of molecular sciences · 2023Review
- Anti-Psoriatic Effects of Antimony Compounds In Vitro.Molecules (Basel, Switzerland) · 2021Article
- The Effect of Herbal Medicinal Products on Psoriasis-Like Keratinocytes.Biomolecules · 2021Article
- Deletion ofFrontiers in cell and developmental biology · 2021Article
- Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor.Frontiers in immunology · 2019Review
- Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology.International journal of molecular sciences · 2018Review
- Cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin 5-positive breast cancer cells.Oncogene · 2017Article
- Article
- Stress Signals, Mediated by Membranous Glucocorticoid Receptor, Activate PLC/PKC/GSK-3β/β-catenin Pathway to Inhibit Wound Closure.The Journal of investigative dermatology · 2017Article
- Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration.Journal of cellular physiology · 2016Article
- Transcriptional regulation analysis and the potential transcription regulator site in the extended KAP6.1 promoter in sheep.Molecular biology reports · 2014Article
- Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner.Molecular and cellular biochemistry · 2014Article
- Glucocorticoid receptor localizes to adherens junctions at the plasma membrane of keratinocytes.PloS one · 2013Article
- Mechanisms of action of topical corticosteroids in psoriasis.International journal of endocrinology · 2012Article
- Keratinocyte-targeted overexpression of the glucocorticoid receptor delays cutaneous wound healing.PloS one · 2012Article
- Glucocorticoid receptors, epidermal homeostasis and hair follicle differentiation.Dermato-endocrinology · 2011Article
- Cortisol synthesis in epidermis is induced by IL-1 and tissue injury.The Journal of biological chemistry · 2011Article
- Hydrocortisone Diffusion Through Synthetic Membrane, Mouse Skin, and Epiderm™ Cultured Skin.Archives of drug information · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Glucocorticoids (GCs), important regulators of epidermal growth, differentiation, and homeostasis, are used extensively in the treatment of skin diseases. Using keratin gene expression as a paradigm of epidermal physiology and pathology, we have developed a model system to study the molecular mechanism of GCs action in skin. Here we describe a novel mechanism of suppression of transcription by the glucocorticoid receptor (GR) that represents an example of customizing a device for transcriptional regulation to target a specific group of genes within the target tissue, in our case, epidermis. We have shown that GCs repress the expression of the basal-cell-specific keratins K5 and K14 and disease-associated keratins K6, K16, and K17 but not the differentiation-specific keratins K3 and K10 or the simple epithelium-specific keratins K8, K18, and K19. We have identified the negative recognition elements (nGREs) in all five regulated keratin gene promoters. Detailed footprinting revealed that the function of nGREs is to instruct the GR to bind as four monomers. Furthermore, using cotransfection and antisense technology we have found that, unlike SRC-1 and GRIP-1, which are not involved in the GR complex that suppresses keratin genes, histone acetyltransferase and CBP are. In addition, we have found that GR, independently from GREs, blocks the induction of keratin gene expression by AP1. We conclude that GR suppresses keratin gene expression through two independent mechanisms: directly, through interactions of keratin nGREs with four GR monomers, as well as indirectly, by blocking the AP1 induction of keratin gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.