ArticleProceedings of the National Academy of Sciences of the United States of America2000
The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 610 papers, 2 of them syntheses that pooled it.
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610 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,669 citations in OpenAlex.
- Systematic synthesis of CRISPR/Cas applications for enhancing salt tolerance in crops: a decade of progress and challenges.BMC plant biology · 2026Pooled it
- Abiotic Stress in Crop Production.International journal of molecular sciences · 2023Pooled it
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- Histone Modification Complex JMJ704-HDA709 Negatively Regulates Salinity Tolerance in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genome-Wide Identification of the WheatPlants (Basel, Switzerland) · 2026Article
- Pixel-registered multimodal synchrotron XRF and FTIR microscopies reveal salinity stress response mechanisms in pistachio.Plant methods · 2026Article
- The SL-MdDWARF53-MdbHLH1 module regulatesHorticulture research · 2026Article
- Integrated biochemical, ionic and ultrastructural analysis of salinity tolerance in novel citrus rootstocks.BMC plant biology · 2026Article
- Genome-wide identification and salt stress-induced expression analysis of the NHX gene family in peanut (Arachis hypogaea L.).BMC plant biology · 2026Article
- Cell-type-specific autophagy in root-hair-forming cells is essential for salt stress tolerance in Arabidopsis thaliana.Nature plants · 2026Article
- Geometric image-based phenotyping and physiological analysis for validation of rice salinity tolerance screening under artificial pot conditions.BMC plant biology · 2026Article
- Dissecting the ROS signalling component of salinity tolerance: tissue-specific K+/Na+ homeostasis in quinoa and spinach roots.Journal of experimental botany · 2026Article
- SALT OVERLY SENSITIVE 1 NaPlant, cell & environment · 2026Article
- ScHAL1-Mediated Enhancement of Salt Tolerance in Soybean: From Stable Transgenic Inheritance to Field Trial Validation.Plant biotechnology journal · 2026Article
- Genome-Wide Identification and Characterization of Stress-Responsive SNARE Genes in Quinoa (Biology · 2026Article
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- Genotype-dependent salt tolerance mechanisms in wheat-Thinopyrum introgression lines revealed by ion transporter gene expression and seedling phenotyping.Scientific reports · 2026Article
- Phytomelatonin in Ornamental Horticulture: A Comprehensive Review of Growth Promotion, Stress Tolerance, and Post-Harvest Quality.International journal of molecular sciences · 2026Review
- Genome-wide identification and expression profiling of the NHX gene family in oat (Avena sativa L.).BMC genomics · 2026Article
550 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In Arabidopsis thaliana, the SOS1 (Salt Overly Sensitive 1) locus is essential for Na(+) and K(+) homeostasis, and sos1 mutations render plants more sensitive to growth inhibition by high Na(+) and low K(+) environments. SOS1 is cloned and predicted to encode a 127-kDa protein with 12 transmembrane domains in the N-terminal part and a long hydrophilic cytoplasmic tail in the C-terminal part. The transmembrane region of SOS1 has significant sequence similarities to plasma membrane Na(+)/H(+) antiporters from bacteria and fungi. Sequence analysis of various sos1 mutant alleles reveals several residues and regions in the transmembrane as well as the tail parts that are critical for SOS1 function in plant salt tolerance. SOS1 gene expression in plants is up-regulated in response to NaCl stress. This up-regulation is abated in sos3 or sos2 mutant plants, suggesting that it is controlled by the SOS3/SOS2 regulatory pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.