ArticleProceedings of the National Academy of Sciences of the United States of America2000
Decoupled evolution of coding region and mRNA expression patterns after gene duplication: implications for the neutralist-selectionist debate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 145 citations in OpenAlex.
- Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network.Nature communications · 2025Article
- Plant Nuclear Factor Y (NF-Y) Transcription Factors: Evolving Insights into Biological Functions and Gene Expansion.International journal of molecular sciences · 2024Review
- The link between gene duplication and divergent patterns of gene expression across a complex life cycle.Evolution letters · 2024Article
- Comparative genomics of sirenians reveals evolution of filaggrin and caspase-14 upon adaptation of the epidermis to aquatic life.Scientific reports · 2024Article
- Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network.bioRxiv : the preprint server for biology · 2024Article
- Retention of duplicated genes in evolution.Trends in genetics : TIG · 2022Review
- Molecular evolution of bumble bee vitellogenin and vitellogenin-like genes.Ecology and evolution · 2021Article
- Genome-Wide Identification of Flowering-Time Genes inInternational journal of molecular sciences · 2018Article
- Population genomics of parallel evolution in gene expression and gene sequence during ecological adaptation.Scientific reports · 2018Article
- Identification and analysis of glutathione S-transferase gene family in sweet potato reveal divergent GST-mediated networks in aboveground and underground tissues in response to abiotic stresses.BMC plant biology · 2017Article
- Article
- The Phenotypic Plasticity of Duplicated Genes in Saccharomyces cerevisiae and the Origin of Adaptations.G3 (Bethesda, Md.) · 2017Article
- Genome-Wide Characterization and Expression Profiling of Sugar Transporter Family in the Whitefly,Frontiers in physiology · 2017Article
- Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors.Molecular biology and evolution · 2015Article
- Maintenance and Loss of Duplicated Genes by Dosage Subfunctionalization.Molecular biology and evolution · 2015Article
- New insights into the evolutionary history of plant sorbitol dehydrogenase.BMC plant biology · 2015Article
- Spatial features for Escherichia coli genome organization.BMC genomics · 2015Article
- Expression divergence between Escherichia coli and Salmonella enterica serovar Typhimurium reflects their lifestyles.Molecular biology and evolution · 2013Article
- Organ evolution in angiosperms driven by correlated divergences of gene sequences and expression patterns.The Plant cell · 2013Article
- The evolutionary pattern and the regulation of stearoyl-CoA desaturase genes.BioMed research international · 2013Article
Corrections and comments
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The neutralist perspective on molecular evolution maintains that the vast majority of mutations affecting gene function are neutral or deleterious. After a gene duplication where both genes are retained, it predicts that original and duplicate genes diverge at clock-like rates. This prediction is usually tested for coding sequences, but can also be applied to another important aspect of gene function, the genes' expression pattern. Moreover, if both sequence and expression pattern diverge at clock-like rates, a correlation between divergence in sequence and divergence in expression patterns is expected. Duplicate gene pairs with more highly diverged sequences should also show more highly diverged expression patterns. This prediction is tested for a large sample of duplicated genes in the yeast Saccharomyces cerevisiae, using both genome sequence and microarray expression data. Only a weak correlation is observed, suggesting that coding sequence and mRNA expression patterns of duplicate gene pairs evolve independently and at vastly different rates. Implications of this finding for the neutralist-selectionist debate are discussed.
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