ArticleProceedings of the National Academy of Sciences of the United States of America2000
Regulation of the actin cycle in vivo by actin filament severing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 101 citations in OpenAlex.
- Suppression of cofilin-1 promotes invasion in 3D hyaluronic acid matrices by promoting actin-based protrusions.Molecular biology of the cell · 2025Article
- Endomucin regulates the endothelial cytoskeleton independently of VEGF.Experimental eye research · 2025Article
- Discrete network models of endothelial cells and their interactions with the substrate.Biomechanics and modeling in mechanobiology · 2024Article
- Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular Leakage.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Actin cytoskeleton in angiogenesis.Biology open · 2022Review
- Interplay between Brownian motion and cross-linking controls bundling dynamics in actin networks.Biophysical journal · 2022Article
- Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility.International journal of molecular sciences · 2022Article
- Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling.Biophysical journal · 2022Article
- Simulations of dynamically cross-linked actin networks: Morphology, rheology, and hydrodynamic interactions.PLoS computational biology · 2021Article
- Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly.Nature communications · 2021Article
- The transcriptomic blueprint of molt in rooster using various tissues from Ginkkoridak (Korean long-tailed chicken).BMC genomics · 2021Article
- Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1.Frontiers in cell and developmental biology · 2021Article
- Neutrophil-like HL-60 cells expressing only GFP-tagged β-actin exhibit nearly normal motility.Cytoskeleton (Hoboken, N.J.) · 2020Article
- Plasma gelsolin promotes re-epithelialization.Scientific reports · 2018Article
- Secretion ofFrontiers in microbiology · 2018Article
- Interplay between cytoskeletal polymerization and the chondrogenic phenotype in chondrocytes passaged in monolayer culture.Journal of anatomy · 2017Article
- Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization.Nature cell biology · 2015Article
- Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics.Scientific reports · 2014Article
- Force mapping during the formation and maturation of cell adhesion sites with multiple optical tweezers.PloS one · 2013Article
- A theoretical analysis of filament length fluctuations in actin and other polymers.Journal of mathematical biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Cycling of actin subunits between monomeric and filamentous phases is essential for cell crawling behavior. We investigated actin filament turnover rates, length, number, barbed end exposure, and binding of cofilin in bovine arterial endothelial cells moving at different speeds depending on their position in a confluent monolayer. Fast-translocating cells near the wound edge have short filament lifetimes compared with turnover values that proportionately increase in slower moving cells situated at increasing distances from the wound border. Contrasted with slow cells exhibiting slow actin filament turnover speeds, fast cells have less polymerized actin, shorter actin filaments, more free barbed ends, and less actin-associated cofilin. Cultured primary fibroblasts manifest identical relationships between speed and actin turnover as the endothelial cells, and fast fibroblasts expressing gelsolin have higher actin turnover rates than slow fibroblasts that lack this actin-severing protein. These results implicate actin filament severing as an important control mechanism for actin cycling in cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.