ArticleJournal of virology2000
H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virus.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Biological risk assessment related to intracerebral injection of TMEV-DA.Archives of virology · 2026Article
- IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler's murine encephalomyelitis virus.Journal of neuroinflammation · 2023Article
- A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.PLoS pathogens · 2018Article
- Host genetic background influences diverse neurological responses to viral infection in mice.Scientific reports · 2017Article
- Interferon-stimulated genes-essential antiviral effectors implicated in resistance to Theiler's virus-induced demyelinating disease.Journal of neuroinflammation · 2015Article
- Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.PloS one · 2014Article
- Targeting the B7 family of co-stimulatory molecules: successes and challenges.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2013Review
- Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L.PLoS pathogens · 2013Article
- Virus expanded regulatory T cells control disease severity in the Theiler's virus mouse model of MS.Journal of autoimmunity · 2011Article
- Restraint stress fails to render C57BL/6 mice susceptible to Theiler's virus-induced demyelination.Neuroimmunomodulation · 2010Article
- Article
- Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.Genetics · 2007Article
- Differential outcome of tolerance induction in naive versus activated Theiler's virus epitope-specific CD8+ cytotoxic T cells.Journal of virology · 2007Article
- Brucella melitensis triggers time-dependent modulation of apoptosis and down-regulation of mitochondrion-associated gene expression in mouse macrophages.Infection and immunity · 2006Article
- Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection.Journal of virology · 2005Article
- Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus.Brain pathology (Zurich, Switzerland) · 2003Article
- Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon.Journal of virology · 2003Article
- Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.Journal of virology · 2002Article
- Bone marrow chimeras reveal non-H-2 hematopoietic control of susceptibility to Theiler's virus persistent infection.Journal of virology · 2002Article
- Capsid-specific cytotoxic T lymphocytes recognize three distinct H-2D(b)-restricted regions of the BeAn strain of Theiler's virus and exhibit different cytokine profiles.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
H-2(b) mice are resistant to persistent infection of the central nervous system by Theiler's virus. They clear the infection 7 to 10 days after intracranial inoculation. Resistance maps to the H-2D gene and not to the H-2K gene and is associated with a potent antiviral cytotoxic T-lymphocyte (CTL) response. We used H-2(b) mice in which the H-2D or the H-2K gene had been inactivated to dissect the respective roles of these genes in resistance. We report that H-2D(-/-) but not H-2K(-/-) mice were susceptible to persistent infection. Furthermore, whereas H-2K(-/-) mice mounted a vigorous virus-specific CTL response, similar to that of control C57BL/6 mice, the CTL response of H-2D(-/-) mice was nil or minimal. Using target cells transfected with the H-2D(b) or the H-2K(b) gene, we showed that the H-2K-restricted CTL response against the virus was minimal in H-2D(-/-) mice. These results demonstrate that the H-2D(b) and H-2K(b) genes play nonredundant roles in the resistance to this persistent infection.
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