ArticleNeurochemical research2000
Antiserum against S-100 protein prevents long term potentiation through a cAMP-related mechanism.
Article in Neurochemical research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Deletion of the calcium-binding protein S100β alters axon initial segment development in the visual cortex.Frontiers in cellular neuroscience · 2026Article
- Levels of serum S100B are associated with cognitive dysfunction in patients with type 2 diabetes.Aging · 2020Article
- Quantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking GPR37 and GPR37L1.Journal of proteome research · 2020Article
- PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation.Journal of neuroinflammation · 2010Article
- A Comparison of the Dynamics of S100B, S100A1, and S100A6 mRNA Expression in Hippocampal CA1 Area of Rats during Long-Term Potentiation and after Low-Frequency Stimulation.Cardiovascular psychiatry and neurology · 2010Article
- Improvement of Memory by Means of Ultra-Low Doses of Antibodies to S-100B Antigen.Evidence-based complementary and alternative medicine : eCAM · 2006Article
- Glutamate uptake is stimulated by extracellular S100B in hippocampal astrocytes.Cellular and molecular neurobiology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long term potentiation (LTP) was induced in the CA1 region of rat hippocampal slices by tetanization of the Schaffer collaterals. Local pretreatment of CA1 with serum of rabbits immunized against S-100 prevented the potentiation. However, treatment of the slices with a membrane permeant cAMP analogue, such as 8-Br-cAMP, could protect against the blocking effect of anti S-100 serum. We suggest that in the rat endogenous S-100b is involved in transduction mechanisms during LTP induction, via its ability to stimulate adenylate cyclase. Possible mechanisms of this action are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.