ArticleJournal of clinical pathology2000
Improved prognosis of Epstein-Barr virus associated childhood Hodgkin's lymphoma: study of 47 South African cases.
Article in Journal of clinical pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- The prognostic value of Epstein-Barr virus infection in Hodgkin lymphoma: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Effect of latent membrane protein 1 expression on overall survival in Epstein-Barr virus-associated cancers: a literature-based meta-analysis.Oncotarget · 2015Pooled it
- Prognostic significance of EBV latent membrane protein 1 expression in lymphomas: evidence from 15 studies.PloS one · 2013Pooled it
- Clinicopathologic patterns and treatment outcomes of pediatric classic hodgkin lymphoma in Ethiopian newly opened cancer treatment centers.BMC pediatrics · 2026Article
- Epstein-Barr virus-based prognostic model in nodular sclerosis classic Hodgkin lymphoma.iScience · 2024Article
- Article
- Tumor-associated macrophages in classical Hodgkin lymphoma: hormetic relationship to outcome.Scientific reports · 2020Article
- Changes in EBV Association Pattern in Pediatric Classic Hodgkin Lymphoma From a Single Institution in Argentina.Frontiers in oncology · 2019Article
- Flow cytometry for assessment of the tumor microenvironment in pediatric Hodgkin lymphoma.Pediatric blood & cancer · 2018Article
- Overview and outcome of Hodgkin's Lymphoma: Experience of a single developing country's oncology centre.PloS one · 2018Article
- Pediatric Hodgkin lymphoma: biomarkers, drugs, and clinical trials for translational science and medicine.Oncotarget · 2016Review
- The Role of Epstein-Barr Virus LMP-1 Immunohistochemical Staining in Childhood Hodgkin Lymphoma.Iranian journal of pediatrics · 2015Article
- Hodgkin lymphoma in childhood: clinicopathological features and therapy outcome at 2 centers from a developing country.Medicine · 2015Article
- EBV in pediatric neoplasia--intensity of infection as independent prognostic factor.Journal of medicine and life · 2012Article
- Prognostic Biomarkers and EBV Infection Research in Diffuse Large B-Cell Lymphoma of the Palatine Tonsils.ISRN oncology · 2012Article
- Macrophages predict treatment outcome in Hodgkin's lymphoma.Haematologica · 2011Article
- Hodgkin lymphoma at the paediatric oncology unit of gabriel touré teaching hospital, bamako, mali: 5-year experience.Advances in hematology · 2011Article
- Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt.Journal of hematopathology · 2010Article
- Association of Hodgkin's lymphoma with Epstein Barr virus infection.Bosnian journal of basic medical sciences · 2007Article
- The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil.Virchows Archiv : an international journal of pathology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the distribution of Hodgkin's lymphoma in South African children and report the incidence of Epstein-Barr virus (EBV) as regards age, race, sex, and histological subtype; to investigate whether EBV is relevant to survival.
methodsImmunohistochemistry (IHC) and in situ hybridisation (ISH) to detect EBV were performed on 47 South African children with classical Hodgkin's lymphoma, ranging in age from 3 to 14 years and coming from different ethnic backgrounds. The correlation between the presence of the virus and clinical outcome was assessed.
resultsThe nodular sclerosing subtype predominated, comprising 89% of cases; the remaining 11% were of the mixed cellularity subtype. EBV was present in 68%. Full clinical data were available for 36 cases; EBV positive patients presented with less aggressive symptoms at diagnosis and had a significantly longer median survival than EBV negative patients.
conclusionsThe distribution of EBV in South African childhood Hodgkin's lymphoma follows a pattern intermediate to that of industrialised and non-industrialized countries. Furthermore, our data suggest that there is an association between poor prognosis and the non-detection of EBV products in South African childhood Hodgkin's lymphoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.