ArticleJournal of clinical pathology2000
Postmortem findings after fatal anaphylactic reactions.
Article in Journal of clinical pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis.Journal of forensic sciences · 2025Pooled it
- Systematic review of outcome measures in trials of pediatric anaphylaxis treatment.BMC pediatrics · 2014Pooled it
- Anaphylactic Shock Probably due to a Cross-Reaction Between Cefuroxime and Piperacillin-Presentation of a Fatal Case, Diagnostic Considerations, and Literature Review.Case reports in critical care · 2026Article
- Liquid chromatography with tandem mass spectrometric method for determination of 52 antibiotics in human whole blood and urine and application to forensic cases.Forensic toxicology · 2024Article
- Anaphylactic deaths: A retrospective study of forensic autopsy cases from 2009 to 2019 in Shanghai, China.Heliyon · 2024Article
- Death Due to Anaphylactic Reaction: The Role of the Forensic Pathologist in an Accurate Postmortem Diagnosis.Medicina (Kaunas, Lithuania) · 2023Review
- Postmortem Biochemistry and Immunohistochemistry in Anaphylactic Death Due to Hymenoptera Sting: A Forensic Case Report.International journal of environmental research and public health · 2023Article
- International recommendations on epinephrine auto-injector doses often differ from standard weight-based guidance: a review and clinical proposals.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Review
- Emergency treatment of anaphylaxis: concise clinical guidance.Clinical medicine (London, England) · 2022Article
- A Clinical Practice Guideline for the Emergency Management of Anaphylaxis (2020).Frontiers in pharmacology · 2022Article
- Interference of hemolysis on the postmortem biochemical analysis of IgE by ECLIA.International journal of legal medicine · 2021Article
- Anaphylactic Death: A New Forensic Workflow for Diagnosis.Healthcare (Basel, Switzerland) · 2021Article
- Article
- Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung · 2021Review
- Reliable Postmortem Molecular Diagnosis of Anaphylaxis: Co-localization of Mast Cell Degranulation and Immunoglobulin E in Allergic Throat Tissues.The American journal of forensic medicine and pathology · 2020Article
- Anaphylaxis: Act Now or Never.JNMA; journal of the Nepal Medical Association · 2020Article
- Global Trends in Anaphylaxis Epidemiology and Clinical Implications.The journal of allergy and clinical immunology. In practice · 2020Article
- Oral Food Challenge.Medicina (Kaunas, Lithuania) · 2019Review
- Medical and pathologic characteristics of fatal anaphylaxis: a Spanish nationwide 17-year series.Forensic science, medicine, and pathology · 2019Article
- Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model.Biomolecules · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the frequency at which classic manifestations of anaphylaxis are present at necropsy after fatal anaphylactic reactions.
methodsA register has been established of fatal anaphylactic reactions in the UK since 1992, traced from the certified cause of death and other sources. Details of the previous medical history and the reaction suggest anaphylaxis as the cause of death for 130 cases; a postmortem report was available for 56.
resultsThe 56 deaths studied included 19 reactions to bee or wasp venom, 16 to foods, and 21 to drugs or contrast media. Death occurred within one hour of anaphylaxis in 39 cases. Macroscopic findings included signs of asthma (mucous plugging and/or hyper-inflated lungs) (15 of 56), petechial haemorrhages (10 of 56), pharyngeal/laryngeal oedema (23 of 56), but for 23 of 56 there was nothing indicative of an allergic death. Mast cell tryptase was raised in 14 of 16 cases tested; three of three tested had detectable IgE specific for the suspected allergen.
conclusionsIn many cases of fatal anaphylaxis no specific macroscopic findings are present at postmortem examination. This reflects the rapidity and mode of death, which is often the result of shock rather than asphyxia. Investigations that might help determine whether anaphylaxis was the cause of death had rarely been performed. In the presence of a typical clinical history, absence of postmortem findings does not exclude the diagnosis of anaphylaxis.
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