ArticleOncogene2000
Caspases and mitochondria in c-Myc-induced apoptosis: identification of ATM as a new target of caspases.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- BAX as the mediator of C-MYC sensitizes acute lymphoblastic leukemia to TLR9 agonists.Journal of translational medicine · 2023Article
- Granzyme B Induces IRF-3 Phosphorylation through a Perforin-Independent Proteolysis-Dependent Signaling Cascade without Inducing Cell Death.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation.Molecular oncology · 2018Article
- Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation.Biology of sex differences · 2018Article
- STAT3 mediates resistance of CD44(+)CD24(-/low) breast cancer stem cells to tamoxifen in vitro.Journal of biomedical research · 2012Article
- Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations.European journal of human genetics : EJHG · 2012Article
- Pemphigus autoimmunity: hypotheses and realities.Autoimmunity · 2012Review
- Discovery of putative oocyte quality markers by comparative ExacTag proteomics.Proteomics. Clinical applications · 2010Article
- Apoptosis Induction by Menadione in Human Promyelocytic Leukemia HL-60 Cells.Toxicological research · 2009Article
- Myc down-regulation affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line.Cell proliferation · 2009Article
- Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated gene.Clinical and experimental immunology · 2008Article
- Identification and characterization of the human inhibitor of caspase-activated DNase gene promoter.Apoptosis : an international journal on programmed cell death · 2008Article
- Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.The Journal of experimental medicine · 2006Article
- ATM and ATR: sensing DNA damage.World journal of gastroenterology · 2004Review
- A decade of caspases.Oncogene · 2003Review
- Linking sister chromatid cohesion and apoptosis: role of Rad21.Molecular and cellular biology · 2002Article
- Article
- The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Expression profiling and interferon-beta regulation of liver metastases in colorectal cancer cells.Clinical & experimental metastasis · 2002Article
- Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia.Clinical and experimental immunology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism(s) of c-Myc transcription factor-induced apoptosis is still obscure. The activation of c-Myc has been found to lead into the processing/activation of caspases (caspase-3), but the significance of this for the cell demise is debatable. Here we report that several targets of caspases (PKCdelta, MDM2, PARP, replication factor C, 70 kDa U1snRNP, fodrin and lamins) are cleaved during c-Myc-induced apoptosis in Rat-1 MycER cells, indicating an important role for caspases in the apoptotic process. We further found that the ATM (ataxia telangiectasia mutated)--protein is a novel key substrate of caspases. In in vitro assays, purified recombinant ATM protein was found to be cleaved by the effector caspases 3 and 7. The functional significance of the ATM cleavage is supported by the finding that ectopic expression of ATM protected in part against apoptosis. We also show that c-Myc-induced apoptosis involves loss of mitochondrial transmembrane potential, release of cytochrome c from mitochondria into the cytosol and subsequent processing of caspase-9. The cleavage of caspase-9 is, however, minimal and a much later event than the processing/activation of caspase-3, suggesting that it is not the apical caspase. Evidence is provided that there is, nevertheless, an upstream caspase(s) regulating the functions of caspase-3 and mitochondria. Additionally, it was found that p53 becomes upregulated, together with its transcriptional targets MDM2 and p21, upon c-Myc induction, but this occurs also at a later time than the activation of caspase-3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.