ArticleOncogene2000
Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- RB loss determines selective resistance and novel vulnerabilities in ER-positive breast cancer models.Oncogene · 2022Article
- Interplay between Cell Death and Cell Proliferation Reveals New Strategies for Cancer Therapy.International journal of molecular sciences · 2022Review
- Cell Cycle Proteins as Key Regulators of Postmitotic Cell Death.The Yale journal of biology and medicine · 2019Review
- Inhibition of pRB Pathway Differentially Modulates Apoptosis in Esophageal Cancer Cells.Translational oncology · 2017Article
- RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy.Oncotarget · 2015Review
- Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis.PloS one · 2014Article
- Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide.Cell death & disease · 2013Article
- pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737.Cell death and differentiation · 2013Article
- Review
- Phosphorylation site mutated RB exerts contrasting effects on apoptotic response to different stimuli.Oncogene · 2006Article
- Tumor promotion by caspase-resistant retinoblastoma protein.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb.Oncogene · 2005Article
- Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons.Journal of molecular neuroscience : MN · 2005Article
- HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway.Oncogene · 2004Article
- Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration.The EMBO journal · 2003Article
- Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases.Leukemia · 2003Article
- Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system.Molecular and cellular biology · 2003Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rb-deficient embryos (Rb-/-) show abnormal degeneration of neurons and die at mid-gestation, suggesting that RB may protect against apoptosis. Having previously shown that cyclin D1 accumulates during K+-induced apoptosis of granule neurons, we chose to investigate the role of RB under these conditions. We show that RB is cleaved in its C-terminus during the onset of neuronal apoptosis. Caspase 3-like activity increases following K+ deprivation and the time course correlates with RB cleavage and apoptosis. Although the use of a specific caspase 3-like inhibitor (z-DEBD.fmk) delays RB cleavage and reduces DNA fragmentation, data implicate other caspases in these processes. However, K+ deprivation induces a gradual production of the active p20 subunit of caspase 3 (CPP32) that coincides with RB disappearance at the cellular level. Nuclear detection of a transfected HA-tagged caspase cleavage-resistant RB mutant (DEAG/D to DEAA/D) revealed a significant decrease in apoptosis of neurons expressing the RB mutant (less than 5%) relative to the wild type form of RB (40%) during K+ deprivation. Taken together, these data show that caspase-dependent cleavage of RB is an early permissive step of the apoptosis-inducing signaling pathway in neurons. They indicate a major role of RB in neuronal protection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.