ArticleBritish journal of pharmacology2000
Tissue angiotensin II and endothelin-1 modulate differently the response to flow in mesenteric resistance arteries of normotensive and spontaneously hypertensive rats.
Article in British journal of pharmacology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- The Angiotensin ATPharmacological reviews · 2022Review
- Testing the Translational Power of the Zebrafish: An Interspecies Analysis of Responses to Cardiovascular Drugs.Frontiers in pharmacology · 2019Article
- Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety.Journal of the American Heart Association · 2018Article
- Inositol 1,4,5-Trisphosphate Receptors in Hypertension.Frontiers in physiology · 2018Review
- Coronary microvascular disease as an early culprit in the pathophysiology of diabetes and metabolic syndrome.Pharmacological research · 2017Review
- Microvascular vasodilator properties of the angiotensin II type 2 receptor in a mouse model of type 1 diabetes.Scientific reports · 2017Article
- AT2 receptor activities and pathophysiological implications.Journal of cardiovascular pharmacology · 2015Review
- Time-related alteration in flow- (shear stress-) mediated remodeling in resistance arteries from spontaneously hypertensive rats.International journal of hypertension · 2014Article
- Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure.Integrated blood pressure control · 2013Review
- COX-2-derived prostanoids and oxidative stress additionally reduce endothelium-mediated relaxation in old type 2 diabetic rats.PloS one · 2013Article
- Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats.International journal of hypertension · 2012Article
- Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats.British journal of pharmacology · 2010Article
- Cyclooxygenase-2 inhibition restored endothelium-mediated relaxation in old obese zucker rat mesenteric arteries.Frontiers in physiology · 2010Article
- AT2 receptors: functional relevance in cardiovascular disease.Pharmacology & therapeutics · 2008Review
- Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice.Diabetes · 2008Article
- Role of the cytoskeleton in flow (shear stress)-induced dilation and remodeling in resistance arteries.Medical & biological engineering & computing · 2008Article
- Role of ACE/AT2R complex in the control of mesenteric resistance artery contraction induced by ACE/AT1R complex activation in response to Ang I.Molecular and cellular biochemistry · 2008Article
- Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats.Hypertension (Dallas, Tex. : 1979) · 2007Article
- Role of angiotensin II receptor subtypes in porcine basilar artery: functional, radioligand binding, and cell culture studies.Life sciences · 2006Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In resistance arteries pressure-induced (myogenic) tone (MT) and flow (shear stress)-induced dilation (FD) are potent determinant of vascular resistance. We investigated the role of angiotensin II and endothelin-1 in FD and MT in resistance arteries and their potential change in hypertension. Flow - diameter - pressure relationship was established in situ, under anaesthesia, in two daughter branches of a mesenteric resistance artery (180 microM, n=7 per group) from spontaneously hypertensive (SHR) or normotensive (WKY) rats. One artery was ligated distally, so that it was submitted to pressure only, while the other was submitted to pressure and flow. Drugs were added to the preparation and external diameter, pressure and flow measured continuously. External diameter (with flow) ranged from 150+/-3 to 191+/-7 microM in WKY (n=28) rats and from 168+/-6 to 186+/-6 microM in SHR (n=28). Flow induced a dilation of the non-ligated arteries which was lower in SHR (13+/-5 - 31+/-4 microM vs WKY: 5+/-5 - 44+/-4 microM). In the ligated artery, the diameter did not significantly change, due to MT. In the vessels submitted to flow angiotensin converting enzyme inhibition (perindopril, 10 micromol L(-1)) increased the diameter in SHR (+11+/-2 microM) significantly more than in WKY (+2+/-1 microM). Angiotensin type 1 receptor (AT(1)R) blockade (losartan, 10 micromol L(-1)) increased the diameter in the vessels with flow in SHR only (+6+/-1 microM). Angiotensin type 2 receptor (AT(2)R) blockade (PD 123319, 1 micromol L(-1)) decreased arterial diameter in WKY only (9+/-2). Endothelin-1 type A receptor (ET(A)R) blockade (LU135252, 0.1 micromol L(-1)) increased the diameter only in SHR in the artery submitted to flow (by 6+/-1 microM). Thus FD was counteracted by a flow-dependent AT(1) and ET(A) receptors-activation in SHR whereas in WKY FD AT(2)-dependent dilation is involved.
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