ReviewJournal of mammary gland biology and neoplasia1998
The role of stroma in breast carcinoma growth in vivo.
Review in Journal of mammary gland biology and neoplasia, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Targeting Cancer-Associated Fibroblasts in Prostate Cancer: Recent Advances and Therapeutic Opportunities.Cancers · 2025Review
- Application of Original Prostate Cancer Progression Model Interacting with Fibroblasts in Preclinical Research.Journal of clinical medicine · 2024Review
- Modeling cancer's ecological and evolutionary dynamics.Medical oncology (Northwood, London, England) · 2023Article
- Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities.Cancers · 2021Review
- Offsetting Expression Profiles of Prognostic Markers in Prostate Tumor vs. Its Microenvironment.Frontiers in oncology · 2019Article
- Role of Stromal Paracrine Signals in Proliferative Diseases of the Aging Human Prostate.Journal of clinical medicine · 2018Review
- Systematic identification of the key candidate genes in breast cancer stroma.Cellular & molecular biology letters · 2018Article
- Targeted blockade of TGF-β and IL-6/JAK2/STAT3 pathways inhibits lung cancer growth promoted by bone marrow-derived myofibroblasts.Scientific reports · 2017Article
- Advances in the development of improved animal-free models for use in breast cancer biomedical research.Biophysical reviews · 2017Review
- Prostate cancer stroma: an important factor in cancer growth and progression.Bosnian journal of basic medical sciences · 2015Review
- Transcriptome analysis of epithelial and stromal contributions to mammogenesis in three week prepartum cows.PloS one · 2011Article
- Expression of cell cycle regulator cdk2ap1 suppresses tumor cell phenotype by non-cell-autonomous mechanisms.Oral oncology · 2009Article
- Improvement in predicting tumorigenic phenotype of androgen-insensitive human LNCaP prostatic cancer cell subline in recombination with rat urogenital sinus mesenchyme.Cancer science · 2008Article
- Collagen density promotes mammary tumor initiation and progression.BMC medicine · 2008Article
- Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors.Breast cancer research : BCR · 2007Article
- Breast cancer progression: insights into multifaceted matrix metalloproteinases.Clinical & experimental metastasis · 2007Review
- Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats.Environmental health perspectives · 2007Article
- Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma.Prostate cancer and prostatic diseases · 2006Article
- A visual-quantitative analysis of fibroblastic stromagenesis in breast cancer progression.Journal of mammary gland biology and neoplasia · 2004Review
- There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions.Journal of clinical pathology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The malignant progression of tumors is thought to be related to the expression of oncogenes and loss of expression of tumor suppressor gene. These factors are intrinsic to the cancer cells themselves. However, carcinomas are also infiltrated by host cells (fibroblasts, endothelial cells, inflammatory cells) and surrounded by an extracellular matrix which is extensively remodeled. The extracellular matrix components and infiltrating host cells provide a microenvironment that conditions both tumor progression and the metastatic process. Transplantation of human tumors into athymic nude mice has become an important experimental approach to study the biology of human cancers. The different models developed so far are beginning to elucidate the role of matrix molecules, growth factors and enzymes as well as fibroblasts in tumor progression. These animal models are likely to provide a useful tool to evaluate new antitumor treatments.
Indexed as
Identifiers
10819529What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.