ReviewJournal of mammary gland biology and neoplasia1998
Roles of hepatocyte growth factor/scatter factor and transforming growth factor-beta1 in mammary gland ductal morphogenesis.
Review in Journal of mammary gland biology and neoplasia, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- A xenotransplantation mouse model to study physiology of the mammary gland from large mammals.PloS one · 2024Article
- Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases.Neoplasia (New York, N.Y.) · 2022Article
- The Mammary Gland: Basic Structure and Molecular Signaling during Development.International journal of molecular sciences · 2022Review
- Review
- Role of ALDH1A1 and HTRA2 expression in CCL2/CCR2-mediated breast cancer cell growth and invasion.Biology open · 2019Article
- The Terminal End Bud: the Little Engine that Could.Journal of mammary gland biology and neoplasia · 2017Review
- Stromal-epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands.Journal of cellular and molecular medicine · 2014Article
- Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- Reprogramming non-mammary and cancer cells in the developing mouse mammary gland.Seminars in cell & developmental biology · 2012Review
- Dual regulation of breast tubulogenesis using extracellular matrix composition and stromal cells.Tissue engineering. Part A · 2012Article
- Adipose stroma induces branching morphogenesis of engineered epithelial tubules.Tissue engineering. Part A · 2010Article
- Diverse and active roles for adipocytes during mammary gland growth and function.Journal of mammary gland biology and neoplasia · 2010Review
- The normal microenvironment directs mammary gland development.Journal of mammary gland biology and neoplasia · 2010Review
- Perfluorooctanoic acid effects on steroid hormone and growth factor levels mediate stimulation of peripubertal mammary gland development in C57BL/6 mice.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Reprogramming cell fates in the mammary microenvironment.Cell cycle (Georgetown, Tex.) · 2009Article
- Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.The American journal of pathology · 2009Article
- Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion.Molecular cancer research : MCR · 2008Article
- Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma.Oncogene · 2005Article
- Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involution.Journal of mammary gland biology and neoplasia · 2003Article
- Establishing a framework for the functional mammary gland: from endocrinology to morphology.Journal of mammary gland biology and neoplasia · 2002Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial-mesenchymal interactions are responsible for the unique pattern of ductal branching morphogenesis characteristic of the mammary gland. To investigate the factors which control the elongation and branching of lactiferous ducts, we developed an in vitro model of ductal morphogenesis in which clonal mouse mammary epithelial cells (TAC-2 cells) are grown in collagen gels. In this experimental system, fibroblast conditioned medium (CM)3 stimulates the formation of extensively arborized tubules. The molecule responsible for this tubulogenic effect was identified as hepatocyte growth factor/scatter factor (HGF/SF). To determine whether HGF/SF plays a role in mammary gland morphogenesis in vivo, the expression of HGF/SF and its receptor, c-Met, were analyzed in the rat mammary gland during pregnancy, lactation, and involution. Levels of HGF/SF and c-Met transcripts were progressively reduced during pregnancy, were virtually undetectable during lactation, and increased again during involution. Collectively, these in vitro and in vivo findings suggest that HGF/SF is a paracrine mediator of mammary gland ductal morphogenesis. We subsequently investigated the effect of another multifunctional cytokine, namely TGF-beta1, on branching morphogenesis of TAC-2 cells. TGF-beta1 had a striking biphasic effect: whereas relatively high concentrations of this cytokine inhibited colony formation, lower concentrations stimulated extensive elongation and branching of epithelial cords. Taken together, these studies indicate that HGF/SF is a stromal-derived paracrine mediator of mammary ductal morphogenesis, and that when present at low concentrations, TGF-beta1 can contribute to this process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.