ReviewJournal of mammary gland biology and neoplasia1998
The mammary gland as a bioreactor: expression, processing, and production of recombinant proteins.
Review in Journal of mammary gland biology and neoplasia, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 97 citations in OpenAlex.
- Genetically modified chickens as bioreactors for protein-based drugs.Frontiers in genome editing · 2024Review
- The transgenic animal platform for biopharmaceutical production.Transgenic research · 2016Review
- Transgenic bovine as bioreactors: Challenges and perspectives.Bioengineered · 2016Review
- Knock-in of Enhanced Green Fluorescent Protein or/and Human Fibroblast Growth Factor 2 Gene into β-Casein Gene Locus in the Porcine Fibroblasts to Produce Therapeutic Protein.Asian-Australasian journal of animal sciences · 2014Article
- The extremely high level expression of human serum albumin in the milk of transgenic mice.Transgenic research · 2012Article
- Expression of human growth hormone in the milk of transgenic rabbits with transgene mapped to the telomere region of chromosome 7q.Journal of applied genetics · 2012Article
- Cloning and Molecular Characterization of Porcine β-casein Gene (CNS2).Asian-Australasian journal of animal sciences · 2012Article
- Characterization of bioactive recombinant human lysozyme expressed in milk of cloned transgenic cattle.PloS one · 2011Article
- Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?Transgenic research · 2010Article
- Production of recombinant albumin by a herd of cloned transgenic cattle.Transgenic research · 2009Article
- Animal pharming, two decades on.Transgenic research · 2008Review
- Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin.BMC biotechnology · 2008Article
- Laparoscopy vs. laparotomy for embryo transfer to produce transgenic goats (Capra hircus).Journal of veterinary science · 2008Article
- Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Carbohydrate phenotyping of human and animal milk glycoproteins.Glycoconjugate journal · 2005Article
- Biomedical and agricultural applications of animal transgenesis.Molecular biotechnology · 2004Review
- A future for transgenic livestock.Nature reviews. Genetics · 2003Review
- Transgenic animal bioreactors.Transgenic research · 2000Review
- Transgenic milk as a method for the production of recombinant antibodies.Journal of immunological methods · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of transgenic animal species are being used to produce recombinant proteins. The general approach is to target the expression of the desired protein to the mammary gland using regulatory elements derived from a milk protein gene and then collect and purify the product from milk. Promoter sequences from a number of different milk protein genes have been used to target expression to the mammary gland, although significant problems remain with regard to achieving transgene expression levels consistent with commercial exploitation. The mammary gland appears to be capable of carrying out the complex posttranslational modifications. such as glycosylation and gamma-carboxylation required for the biological activity and stability of specific proteins. Effective purification protocols have been established and products produced by this route have now entered clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.