ReviewJournal of mammary gland biology and neoplasia1998
Origin and secretion of milk lipids.
Review in Journal of mammary gland biology and neoplasia, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Weighted gene co-expression network analysis identifies modules and functionally enriched pathways in the lactation process.Scientific reports · 2021Pooled it
- In Vitro Model of Milking Pulses and Stretching Cycles: Assessing Mechanical Effects on Bovine Mammary Cells.Journal of mammary gland biology and neoplasia · 2026Article
- Long non-coding RNA MLST promotes milk fat synthesis in bovine mammary epithelial cells by sponging miR-7 to activate the mTOR signal pathway.Journal of animal science · 2026Article
- Article
- A comparative proteomic, transcriptomic and glycomic analysis of extracellular vesicle isolation techniques highlights ExoGAG efficiency for a more complete identification of breast milk molecular signaling pathways.Cell communication and signaling : CCS · 2025Article
- Deciphering the role of MFGE8 in lactation using CRISPR-CAS9 based gene editing in Buffalo mammary epithelial cells.Scientific reports · 2025Article
- Characterization of mammary glands and milk fat globule transcripts in lactating buffalo and goats.Food chemistry. Molecular sciences · 2025Article
- A mammary gland secretion function exploratory study based on a quantitative comparison between milk and serum.Molecular and cellular biochemistry · 2025Article
- Inversely Correlated Restoration of Body Condition Score and Systemic Metabolic Burden in Lactating Cows: Implications for Milk Fat Globule Size and Mitigation of Negative Energy Balance Effects on Milk Fat Composition.International journal of molecular sciences · 2025Article
- How Close Are We to the Production of Milk in Alternative Systems? The Fat Perspective.Foods (Basel, Switzerland) · 2025Review
- Revealing gene expression links between milk fat globules and mammary glands in rodents via transcriptomics.Frontiers in veterinary science · 2025Article
- Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids.International journal of pharmaceutics: X · 2024Review
- Comparative analysis of the effects of different purification methods on the yield and purity of cow milk extracellular vesicles.Journal of extracellular biology · 2024Article
- Article
- Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion.Frontiers in molecular biosciences · 2023Article
- Enhanced Goat Milk MUFA QualityInternational journal of food science · 2023Article
- Article
- Circ003429 Regulates Unsaturated Fatty Acid Synthesis in the Dairy Goat Mammary Gland by Interacting with miR-199a-3p, Targeting theInternational journal of molecular sciences · 2022Article
- Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland.Frontiers in cell and developmental biology · 2022Article
- The milk fat globule size governs a physiological switch for biofilm formation byFrontiers in nutrition · 2022Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cream fraction of milk comprises droplets of triacylglycerol coated with cellular membranes. In this review, we discuss how these droplets are formed and secreted from mammary epithelial cells during lactation. This secretory system is especially interesting because the assembled lipid droplets are secreted from the cytoplasm enveloped by cellular membranes. In other cells, such as hepatocytes and enterocytes, lipid is secreted by exocytosis from membrane-bounded compartments of the secretory pathway. Milk lipids originate as small droplets of triacylglycerol, synthesized in or on the surfaces of rough endoplasmic reticulum (ER)4 membranes. These droplets are released into the cytoplasm as microlipid droplets (MLDs) with a surface coat of protein and polar lipid. MLDs may fuse with each other to form larger cytoplasmic lipid droplets (CLDs). Droplets of varying size, are transported to the apical cytoplasm by unknown mechanisms and are secreted from the cell coated with an outer bilayer membrane. CLDs may increase in size in all regions of the cell, especially at the plasma membrane during secretion. Two possible mechanisms for lipid secretion have been proposed: an apical mechanism, in which lipid droplets are enveloped with apical plasma membrane, and a secretory-vesicle mechanism, in which fat droplets are surrounded by secretory vesicles in the cytoplasm and are released from the surface by exocytosis from intracytoplasmic vacuoles. A combination of both mechanisms may be possible. Following secretion, a fraction of the membrane surrounding the globules may be shed from the droplets and give rise to membrane fragments in the skim milk phase.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.