ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners1999
Antidepressants and the serotonin syndrome in general practice.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Precipitants and clinical features of serotonin syndrome: a systematic review with patient-level analysis of published case reports and series.European journal of clinical pharmacology · 2026Pooled it
- Conundrums in neurology: diagnosing serotonin syndrome - a meta-analysis of cases.BMC neurology · 2016Pooled it
- Dextromethorphan, chlorphenamine and serotonin toxicity: case report and systematic literature review.British journal of clinical pharmacology · 2010Pooled it
- Comparative risk for harms of second-generation antidepressants : a systematic review and meta-analysis.Drug safety · 2008Pooled it
- Article
- Predictors of Serotonin Syndrome in Acute Poisoning with 5-Hydroxytryptamine Modulators.Toxics · 2024Article
- Serotonin syndrome controversies: A need for consensus.World journal of critical care medicine · 2024Review
- Neuroleptic malignant syndrome and serotonin syndrome: a comparative bibliometric analysis.Orphanet journal of rare diseases · 2024Review
- Cyproheptadine in serotonin syndrome: A retrospective study.Journal of family medicine and primary care · 2024Article
- Article
- Review
- Serotonin syndrome in the acute treatment landscape of migraine: the lasmiditan experience.Frontiers in neurology · 2023Article
- Serotonin syndrome caused by a CYP2C19-mediated interaction between low-dose escitalopram and clopidogrel: a case report.Frontiers in psychiatry · 2023Article
- Recognition and Management of Serotonin Toxidrome in the Emergency Department-Case Based Review.Journal of personalized medicine · 2022Review
- Clinical relevance of alerts from a decision support system, PHARAO, for drug safety assessment in the older adults.BMC geriatrics · 2019Article
- The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice.International journal of molecular sciences · 2019Review
- An atypical case of serotonin syndrome with normal dose of selective serotonin inhibitors: A case report.Medicine · 2019Article
- Takotsubo cardiomyopathy associated with serotonin syndrome in a patient with stroke: A case report.Medicine · 2019Article
- Serotonin Syndrome: Pathophysiology, Clinical Features, Management, and Potential Future Directions.International journal of tryptophan research : IJTR · 2019Review
- Case of Serotonin Syndrome Initially Presenting as Diffuse Body Pain.The American journal of case reports · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a consequence of the greater use of agents affecting the serotonergic system, a syndrome of serotonin hyperstimulation has been recognized more frequently. The serotonin syndrome is characterized by a constellation of symptoms that include mental status changes, agitation, myoclonus, hyperreflexia, sweating, shivering, tremor, diarrhoea, lack of coordination, and fever. Deaths have been reported.
aimTo identify cases of the serotonin syndrome among patients prescribed a new antidepressant in general practice, and to determine doctors' awareness of the syndrome.
methodPatients who were dispensed nefazodone in England between 1996 and 1997 were identified using dispensed prescription data. Prescribing doctors were sent questionnaires as part of a post-marketing surveillance study. Patients reported to have experienced two or more features of the serotonin syndrome were identified, and specific questionnaires were sent to their general practitioners.
resultsThere was a 96.2% return rate of serotonin syndrome questionnaires. Nineteen cases met criteria for the syndrome (incidence = 0.4 cases per 1000 patient-months of treatment with nefazodone). Eight patients developed symptoms while taking nefazodone alone. Serotonergic symptoms were reported to a similar degree with five other antidepressants studied by the same method. In total, 85.4% of responding general practitioners were unaware of the serotonin syndrome.
conclusionImproved awareness of the syndrome is needed within general practice. There is a need to distinguish the relatively minor serotonergic symptoms from those of a severe, life-threatening serotonin syndrome.
Indexed as
Identifiers
10818650PMC1313555W1909234973What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.