ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Cytoskeletal links of neuronal acetylcholine receptors containing alpha 7 subunits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes.ACS chemical neuroscience · 2024Article
- Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses.Current opinion in virology · 2019Review
- Nicotine Effects and Receptor Expression on Human Spermatozoa: Possible Neuroendocrine Mechanism.Frontiers in physiology · 2017Article
- Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.Neuropharmacology · 2016Article
- Roles of nicotinic acetylcholine receptor β subunit cytoplasmic loops in acute desensitization and single-channel features.Neuroscience · 2015Article
- Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Article
- Sperm epidermal growth factor receptor (EGFR) mediates α7 acetylcholine receptor (AChR) activation to promote fertilization.The Journal of biological chemistry · 2012Article
- Abelson family tyrosine kinases regulate the function of nicotinic acetylcholine receptors and nicotinic synapses on autonomic neurons.Molecular pharmacology · 2011Article
- The effects of aging vs. α7 nAChR subunit deficiency on the mouse brain transcriptome: aging beats the deficiency.Age (Dordrecht, Netherlands) · 2011Article
- Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Proteomic analysis of an alpha7 nicotinic acetylcholine receptor interactome.Journal of proteome research · 2009Article
- Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex.Molecular and cellular neurosciences · 2008Article
- Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Structural answers and persistent questions about how nicotinic receptors work.Frontiers in bioscience : a journal and virtual library · 2008Review
- An acute effect of neuregulin 1 beta to suppress alpha 7-containing nicotinic acetylcholine receptors in hippocampal interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model.Neuron · 2004Article
- Ultrastructure of a somatic spine mat for nicotinic signaling in neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Synaptically driven calcium transients via nicotinic receptors on somatic spines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nicotinic acetylcholine receptors serve a variety of signaling functions in the nervous system depending on cellular location, but little is known about mechanisms responsible for tethering them at specific sites. Among the most interesting are receptors containing the alpha7 gene product, because of their abundance and high relative permeability to calcium. On chick ciliary ganglion neurons alpha7-containing receptors are highly concentrated on somatic spines folded into discrete patches on the cell. We show that the spines contain filamentous actin and drebrin. After cell dissociation, the actin slowly redistributes, the spines retract, and the alpha7-containing receptors disperse and are subsequently lost from the surface. Latrunculin A, a drug that depolymerizes filamentous actin, accelerates receptor dispersal, whereas jasplikinolide, a drug that stabilizes the actin cytoskeleton, preserves large receptor clusters and prevents receptor loss from the surface. The receptors are resistant to extraction by nonionic detergent even after latrunculin A treatment. Other, less abundant, nicotinic receptors on the neurons are readily solubilized by the detergent even though these receptors are located in part on the spines. The results demonstrate that the actin cytoskeleton is important for retaining receptor-rich spines and indicate that additional cytoskeletal elements or molecular interactions specific for alpha7-containing receptors influence their fate in the membrane. The cytoskeletal elements involved are not dependent on the architecture of the postsynaptic density because alpha7-containing receptors are excluded from such sites on ciliary ganglion neurons.
Indexed as
Identifiers
10818137PMC6772650W1673863031What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.