ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Role of cAMP cascade in synaptic stability and plasticity: ultrastructural and physiological analyses of individual synaptic boutons in Drosophila memory mutants.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
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- Inter-relationships among physical dimensions, distal-proximal rank orders, and basal GCaMP fluorescence levels in CaJournal of neurogenetics · 2018Article
- Secreted tissue inhibitor of matrix metalloproteinase restrictsJournal of cell science · 2017Article
- The influence of postsynaptic structure on missing quanta at the Drosophila neuromuscular junction.BMC neuroscience · 2016Article
- The role of cAMP in synaptic homeostasis in response to environmental temperature challenges and hyperexcitability mutations.Frontiers in cellular neuroscience · 2015Article
- A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain.PLoS genetics · 2013Article
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- Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease.Human molecular genetics · 2012Article
- Cyclic adenosine monophosphate metabolism in synaptic growth, strength, and precision: neural and behavioral phenotype-specific counterbalancing effects between dnc phosphodiesterase and rut adenylyl cyclase mutations.Journal of neurogenetics · 2012Article
- Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Stimulation-induced formation of the reserve pool of vesicles in Drosophila motor boutons.Journal of neurophysiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations of the genes rutabaga (rut) and dunce (dnc) affect the synthesis and degradation of cAMP, respectively, and disrupt learning in Drosophila. Combined ultrastructural analysis and focal electrophysiological recording in the larval neuromuscular junction revealed a loss of stability and fine tuning of synaptic structure and function in both mutants. Increased ratios of docked/undocked vesicles and poorly defined synaptic specializations characterized dnc synapses. In contrast, rut boutons possessed fewer, although larger, synapses with lower proportions of docked vesicles. At reduced Ca(2+) levels, decreased quantal content coupled with an increase in failure rate was seen in rut boutons and reduced pair-pulse facilitation were found in both rut and dnc mutants. At physiological Ca(2+) levels, strong enhancement, instead of depression, in evoked release was observed in some dnc and rut boutons during 10 Hz tetanus. Furthermore, increased variability of synaptic transmission, including fluctuation and asynchronicity of evoked release, paralleled an increase in synapse size variation in both dnc and rut boutons, which might impose problems for effective signal processing in the nervous system. Pharmacological and genetic studies indicated broader ranges of physiological alteration by dnc and rut mutations than either the acute effects of cAMP analogs or the available mutations that affect cAMP-dependent protein kinase (PKA) activity. This is consistent with previous reports of more severe learning defects in dnc and rut mutations than these PKA mutants and allows identification of the phenotypes involving long-term developmental regulation and those conferred by PKA.
Indexed as
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10818133PMC6772635W2117020954What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.