ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 74 citations in OpenAlex.
- Involvement of CaCellular and molecular neurobiology · 2023Article
- KJournal of neurophysiology · 2021Article
- PIPInternational journal of molecular sciences · 2020Article
- Modulation of CaBMC research notes · 2018Article
- Neurotensinergic Excitation of Dentate Gyrus Granule Cells via Gαq-Coupled Inhibition of TASK-3 Channels.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Phosphoinositides regulate ion channels.Biochimica et biophysica acta · 2015Review
- Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized β subunit.The Journal of general physiology · 2014Article
- Gq rather than G11 preferentially mediates nociceptor sensitization.Molecular pain · 2013Article
- Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.Cellular signalling · 2012Article
- GPCR mediated regulation of synaptic transmission.Progress in neurobiology · 2012Review
- Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Inhibition of transmitter release from rat sympathetic neurons via presynaptic M(1) muscarinic acetylcholine receptors.British journal of pharmacology · 2009Article
- PIP(2)-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP(2) depletion by Gq-coupled receptors in single living neurons.Pflugers Archiv : European journal of physiology · 2007Article
- MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Excitatory muscarinic modulation strengthens virtual nicotinic synapses on sympathetic neurons and thereby enhances synaptic gain.Journal of neurophysiology · 2006Article
- M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.Pharmacological reviews · 2006Review
- Functions of neuronal P2Y receptors.Pflugers Archiv : European journal of physiology · 2006Review
- Probing the regulation of M (Kv7) potassium channels in intact neurons with membrane-targeted peptides.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Regulation of neuronal ion channels via P2Y receptors.Purinergic signalling · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Activation of M(1) muscarinic acetylcholine receptors (M(1) mAChR) inhibits M-type potassium currents (I(K(M))) and N-type calcium currents (I(Ca)) in mammalian sympathetic ganglia. Previous antisense experiments suggested that, in rat superior cervical ganglion (SCG) neurons, both effects were partly mediated by the G-protein Galpha(q) (Delmas et al., 1998a; Haley et al., 1998a), but did not eliminate a contribution by other pertussis toxin (PTX)-insensitive G-proteins. We have tested this further using mice deficient in the Galpha(q) gene. PTX-insensitive M(1) mAChR inhibition of I(Ca) was strongly reduced in Galpha(q) -/- mouse SCG neurons and was fully restored by acute overexpression of Galpha(q). In contrast, M(1) mAChR inhibition of I(K(M)) persisted in Galpha(q)-/- mouse SCG cells. However, unlike rat SCG neurons, muscarinic inhibition of I(K(M)) was partly PTX-sensitive. Residual (PTX-insensitive) I(K(M)) inhibition was slightly reduced in Galpha(q) -/- neurons, and the remaining response was then suppressed by anti-Galpha(q/11) antibodies. Bradykinin (BK) also inhibits I(K(M)) in rat SCG neurons via a PTX-insensitive G-protein (G(q) and/or G(11); Jones et al., 1995). In mouse SCG neurons, I(K(M)) inhibition by BK was fully PTX-resistant. It was unchanged in Galpha(q) -/- mice but was abolished by anti-Galpha(q/11) antibody. We conclude that, in mouse SCG neurons (1) M(1) mAChR inhibition of I(Ca) is mediated principally by G(q), (2) M(1) mAChR inhibition of I(K(M)) is mediated partly by G(q), more substantially by G(11), and partly by a PTX-sensitive G-protein(s), and (3) BK-induced inhibition of I(K(M)) is mediated wholly by G(11).
Indexed as
Identifiers
10818132PMC6772644W2132298210What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.