ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Neuromodulatory effects of gonadotropin releasing hormone on olfactory receptor neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 155 citations in OpenAlex.
- Behavioral, Endocrine, and Neuronal Responses to Odors in Lampreys.Animals : an open access journal from MDPI · 2025Review
- Article
- Physiological Effects and Transcriptomic Analysis of sbGnRH on the Liver in Pompano (Frontiers in endocrinology · 2022Article
- The evolutionary origins of the vertebrate olfactory system.Open biology · 2020Review
- Cyclophosphamide has Long-Term Effects on Proliferation in Olfactory Epithelia.Chemical senses · 2020Article
- Male dominance status regulates odor-evoked processing in the forebrain of a cichlid fish.Scientific reports · 2019Article
- Multiple functions of non-hypophysiotropic gonadotropin releasing hormone neurons in vertebrates.Zoological letters · 2019Review
- GnRH suppresses excitability of visual processing neurons in the optic tectum.Journal of neurophysiology · 2015Article
- Dynamic evolution of the GnRH receptor gene family in vertebrates.BMC evolutionary biology · 2014Article
- Central pathways integrating metabolism and reproduction in teleosts.Frontiers in endocrinology · 2014Review
- Burst generation mediated by cholinergic input in terminal nerve-gonadotrophin releasing hormone neurones of the goldfish.The Journal of physiology · 2013Article
- Article
- Characterization of voltage-activated ionic currents in the GnRH-containing terminalis nerve in transgenic zebrafish.Brain research · 2011Article
- Reproductive status regulates expression of sex steroid and GnRH receptors in the olfactory bulb.Behavioural brain research · 2010Article
- Social status regulates kisspeptin receptor mRNA in the brain of Astatotilapia burtoni.General and comparative endocrinology · 2010Article
- Acquisition of spontaneous electrical activity during embryonic development of gonadotropin-releasing hormone-3 neurons located in the terminal nerve of transgenic zebrafish (Danio rerio).General and comparative endocrinology · 2010Article
- Odors activate dual pathways, a TRPC2 and a AA-dependent pathway, in mouse vomeronasal neurons.American journal of physiology. Cell physiology · 2010Article
- The role of the terminal nerve and GnRH in olfactory system neuromodulation.Zoological science · 2009Review
- mRNA expression of GnRH variants and receptors in the brain, pituitary and ovaries of pejerrey (Odontesthes bonariensis) in relation to the reproductive status.Fish physiology and biochemistry · 2009Article
- The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice.Endocrinology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The terminal nerve is an anterior cranial nerve that innervates the lamina propria of the chemosensory epithelia of the nasal cavity. The function of the terminal nerve is ambiguous, but it has been suggested to serve a neuromodulatory role. We tested this hypothesis by exposing olfactory receptor neurons from mudpuppies (Necturus maculosus) to a peptide, gonadotropin releasing hormone (GnRH), that is found in cells and fibers of the terminal nerve. We used voltage-clamped whole-cell recordings to examine the effects of 0. 5-50 micrometer GnRH on voltage-activated currents in olfactory receptor neurons from epithelial slices. We found that GnRH increases the magnitude, but does not alter the kinetics, of a tetrodotoxin-sensitive inward current. This increase in magnitude generally begins 5-10 min after initial exposure to GnRH, is sustained for at least 60 min during GnRH exposure, and recovers to baseline within 5 min after GnRH is washed off. This effect occurred in almost 60% of the total number of olfactory receptor neurons examined and appeared to be seasonal: approximately 67% of neurons responded to GnRH during the courtship and mating season, compared with approximately 33% during the summer, when the sexes separate. GnRH also appears to alter an outward current in the same cells. Taken together, these data suggest that GnRH increases the excitability of olfactory receptor neurons and that the terminal nerve functions to modulate the odorant sensitivity of olfactory receptor neurons.
Indexed as
Identifiers
10818129PMC6772656W2140340130What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.