ArticleAntimicrobial agents and chemotherapy2000
Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model.Pharmaceutical research · 2010Article
- Effluxing ABC transporters in human corneal epithelium.Journal of pharmaceutical sciences · 2010Article
- ABC transporters and isothiocyanates: potential for pharmacokinetic diet-drug interactions.Biopharmaceutics & drug disposition · 2009Article
- Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection.Pharmaceutical research · 2007Article
- Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux.International journal of pharmaceutics · 2007Article
- Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells.BMC cancer · 2006Article
- Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.Antimicrobial agents and chemotherapy · 2006Article
- ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.Cancer cell international · 2005Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythromycin enhanced sensitivity with increased intracellular vincristine accumulation and inhibited the calcein-AM efflux. Our findings suggest that the two agents are possible MRP substrates and may competitively inhibit MRP function as a drug efflux pump.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.