ArticleInfection and immunity2000
Identification and characterization of murine cytotoxic T cells that kill Mycobacterium tuberculosis.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 90 citations in OpenAlex.
- Coordinated In Vitro Release of Granulysin, Perforin and IFN-γ in TB and HIV/TB Co-Infection Associated with Clinical Outcomes before and after Anti-TB Treatment.Pathogens (Basel, Switzerland) · 2020Article
- The Injectable Contraceptive Medroxyprogesterone Acetate Attenuates Mycobacterium tuberculosis-Specific Host Immunity Through the Glucocorticoid Receptor.The Journal of infectious diseases · 2019Article
- Macrophage-microbe interaction: lessons learned from the pathogen Mycobacterium tuberculosis.Seminars in immunopathology · 2018Review
- Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Potential Effect of Statins onJournal of immunology research · 2018Review
- Macrophage Immune Response Suppression by Recombinant Mycobacterium tuberculosis Antigens, the ESAT-6, CFP-10, and ESAT-6/CFP-10 Fusion Proteins.Iranian journal of medical sciences · 2016Article
- The Mycobacterium bovis BCG prime-Rv0577 DNA boost vaccination induces a durable Th1 immune response in mice.Acta biochimica et biophysica Sinica · 2016Article
- High-frequency vaccine-induced CD8⁺ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection.European journal of immunology · 2014Article
- Immunotherapy of tuberculosis with Mycobacterium leprae Hsp65 as a DNA vaccine triggers cross-reactive antibodies against mammalian Hsp60 but not pathological autoimmunity.Human vaccines & immunotherapeutics · 2014Article
- CD4 CTL: living up to the challenge.Seminars in immunology · 2013Review
- The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria?Clinical & developmental immunology · 2012Review
- Perforin level in CD4+ T cells from patients with systemic lupus erythematosus.Rheumatology international · 2010Article
- Direct microbicidal activity of cytotoxic T-lymphocytes.Journal of biomedicine & biotechnology · 2010Review
- Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.Tissue antigens · 2009Review
- Article
- Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Impaired expression of perforin and granulysin in CD8+ T cells at the site of infection in human chronic pulmonary tuberculosis.Infection and immunity · 2007Article
- Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.Clinical and experimental immunology · 2007Article
- Improve protective efficacy of a TB DNA-HSP65 vaccine by BCG priming.Genetic vaccines and therapy · 2007Article
- Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunity.Critical reviews in immunology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As we seek to develop and evaluate new vaccines against tuberculosis, it is desirable that we understand the mechanisms of protective immunity in our models. Adoptive transfer of protection with hsp65-specific T-cell clones from infected or vaccinated mice into naïve mice had indicated that cytotoxic T cells can make a major contribution to protection. We characterized 28 CD4(+) CD8(-) and 28 CD4(-) CD8(+) hsp65-specific T-cell clones derived from infected or vaccinated mice. Half of the CD4(+) CD8(-) and 64% of the CD4(-) CD8(+) clones were cytotoxic. Cytotoxicity was associated with high expression of CD44 and gamma interferon production. Most (86%) of the cytotoxic CD4(+) CD8(-) clones lysed target cells via the Fas-FasL pathway, and most (83%) of the cytotoxic CD4(-) CD8(+) clones lysed target cells via cytotoxic granules. Only the clones using the granule-mediated pathway caused substantial loss of viability of virulent Mycobacterium tuberculosis during lysis of infected macrophages, and the degree of killing closely correlated with the availability of granule marker enzyme activity. Granule-mediated cytotoxicity thus may have a key role in protection against tuberculosis by delivering mycobactericidal granule contents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.