ArticleOncogene2000
Evi27 encodes a novel membrane protein with homology to the IL17 receptor.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 67 citations in OpenAlex.
- IL-25 induces airway remodeling in asthma by orchestrating the phenotypic changes of epithelial cell and fibrocyte.Respiratory research · 2023Article
- Review
- The IL-17B-IL-17 receptor B pathway promotes resistance to paclitaxel in breast tumors through activation of the ERK1/2 pathway.Oncotarget · 2017Article
- Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.Scientific reports · 2016Article
- Article
- A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation.PLoS pathogens · 2014Article
- Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway.Oncogene · 2014Article
- Codon optimization, expression, purification, and functional characterization of recombinant human IL-25 in Pichia pastoris.Applied microbiology and biotechnology · 2013Article
- The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex.BMC pulmonary medicine · 2011Article
- Structure and function of interleukin-17 family cytokines.Protein & cell · 2011Review
- IL-17 family member cytokines: regulation and function in innate immunity.Cytokine & growth factor reviews · 2010Review
- IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo.Cancer immunology, immunotherapy : CII · 2010Article
- Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2009Review
- Barrier immunity and IL-17.Seminars in immunology · 2009Review
- Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- The IL-17 cytokine family and their role in allergic inflammation.Current opinion in immunology · 2008Review
- Regulation and pro-inflammatory function of interleukin-17 family cytokines.Immunological reviews · 2008Review
- Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines.Pharmacology & therapeutics · 2008Review
- Animal models of acute myelogenous leukaemia - development, application and future perspectives.Leukemia · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evi27 is a common site of retroviral integration in BXH2 murine myeloid leukemias. Here we show that integration at Evi27 occurs in a CpG island approximately 6 kb upstream from a novel gene (designated Evii27) with homology to the IL17 receptor (Il17r) and that proviral integrations result in increased expression of the Evi27 protein on the cell surface. The human EVI27 homolog was also cloned and mapped to chromosome 3p21. Multiple Evi27 isoforms were detected at the RNA and protein level in both human and mouse, indicating that Evi27 expression is complex. Some of the isoforms are shown to likely represent secreted soluble forms of the protein produced by intron incorporation or by proteolytic cleavage. In the mouse, highest Evi27 expression occurs in liver and testes with lower expression in kidney and lung. In humans, EVI27 is expressed at high levels in the kidney, with moderate levels in the liver, brain, and testes. Within hematopoietic cells, Evi27 expression is restricted. Northern and Western analysis showed that Evi27 is expressed in selected T-cell, B-cell and myeloid cell lines. These results suggest that Evi27 expression is tightly regulated during hematopoietic differentiation. Collectively, these studies identify a new member of the cytokine receptor family whose increased and uncoordinated expression may lead to myeloid leukemia by altering Evi27's normal ability to control the growth and/or differentiation of hematopoietic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.