ReviewCritical reviews in eukaryotic gene expression2000
Cell nucleus in context.
Review in Critical reviews in eukaryotic gene expression, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The likely role of proteolytic enzymes in unwanted differentiation of stem cells in culture.Future science OA · 2015Review
- mTOR signal transduction pathways contribute to TN-C FNIII A1 overexpression by mechanical stress in osteosarcoma cells.Molecules and cells · 2014Article
- NuMA after 30 years: the matrix revisited.Trends in cell biology · 2010Review
- Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control.Biochimica et biophysica acta · 2009Review
- Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.Annals of the rheumatic diseases · 2007Review
- Phenotype clustering of breast epithelial cells in confocal images based on nuclear protein distribution analysis.BMC cell biology · 2007Article
- Automated local bright feature image analysis of nuclear protein distribution identifies changes in tissue phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2.Journal of cell science · 2005Article
- Modeling tissue-specific signaling and organ function in three dimensions.Journal of cell science · 2003Review
- Functional analysis of an arthritogenic synovial fibroblast.Arthritis research & therapy · 2003Article
- The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state?The Journal of clinical investigation · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The molecular pathways that participate in regulation of gene expression are being progressively unraveled. Extracellular signals, including the binding of extracellular matrix and soluble molecules to cell membrane receptors, activate specific signal transducers that process information inside the cell leading to alteration in gene expression. Some of these transducers when translocated to the cell nucleus may bind to transcription complexes and thereby modify the transcriptional activity of specific genes. However, the basic molecules involved in the regulation of gene expression are found in many different cell and tissue types; thus, the mechanisms underlying tissue-specific gene expression are still obscure. In this review we focus on the study of signals that are conveyed to the nucleus. We propose that the way in which extracellular signals are integrated may account for tissue-specific gene expression. We argue that the integration of signals depends on the nature of the structural organization of cells (i.e., extracellular matrix, membrane proteins, cytoskeleton, nucleus) that defines a particular cell type within a tissue. Thus, gene expression can be envisioned as being regulated by the mutual influence of extracellular and intracellular organizations, i.e., in context.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.