ArticleProceedings of the National Academy of Sciences of the United States of America2000
Differential activation of a Candida albicans virulence gene family during infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 151 citations in OpenAlex.
- Pathogen virulence genes: Advances, challenges and future directions in infectious disease research (Review).International journal of molecular medicine · 2025Review
- Internal transcribed spacer sequencing to explore the intrinsic composition of fungal communities in fungal esophagitis.World journal of gastroenterology · 2025Article
- Anti-virulence strategy of diaryl chalcogenide compounds againstVirulence · 2023Article
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- Functional analysis of the3 Biotech · 2022Article
- Amino Acid Sensing and Assimilation by the Fungal PathogenPathogens (Basel, Switzerland) · 2021Review
- The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence.Cell reports · 2021Article
- Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients.Applied microbiology and biotechnology · 2021Article
- Generation of Viable Candida albicans Mutants Lacking the "Essential" Protein Kinase Snf1 by Inducible Gene Deletion.mSphere · 2020Article
- (1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition.Microbial biotechnology · 2018Article
- Tipping the Balance:Journal of fungi (Basel, Switzerland) · 2018Review
- Genomic and Phenotypic Variation in Morphogenetic Networks of TwoFrontiers in immunology · 2017Article
- Article
- In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life?PLoS pathogens · 2016Review
- Transcriptional Profiling of Candida albicans in the Host.Methods in molecular biology (Clifton, N.J.) · 2016Article
- A New Endogenous Overexpression System of Multidrug Transporters of Candida albicans Suitable for Structural and Functional Studies.Frontiers in microbiology · 2016Article
- Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis.Infection and immunity · 2015Article
- Kinin release from human kininogen by 10 aspartic proteases produced by pathogenic yeast Candida albicans.BMC microbiology · 2015Article
- The spectrum of fungi that infects humans.Cold Spring Harbor perspectives in medicine · 2014Review
- Role of Candida albicans-secreted aspartyl proteinases (Saps) in severe early childhood caries.International journal of molecular sciences · 2014Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yeast Candida albicans is a harmless commensal in most healthy people, but it causes superficial as well as life-threatening systemic infections in immunocompromised patients. C. albicans can colonize or infect virtually all body sites because of its high adaptability to different host niches, which involves the activation of appropriate sets of genes in response to complex environmental signals. We have used an in vivo expression technology that is based on genetic recombination as a reporter of gene expression to monitor the differential activation of individual members of a gene family encoding secreted aspartic proteinases (Saps), which have been implicated in C. albicans virulence, at various stages of the infection process. Our results demonstrate that SAP expression depends on the type of infection, with different SAP isogenes being activated during systemic disease as compared with mucosal infection. In addition, the activation of individual SAP genes depends on the progress of the infection, some members of the gene family being induced immediately after contact with the host, whereas others are expressed only after dissemination into deep organs. In the latter case, the number of invading organisms determines whether induction of a virulence gene is necessary for successful infection. The in vivo expression technology allows the elucidation of gene expression patterns at different stages of the fungus-host interaction, thereby revealing regulatory adaptation mechanisms that make C. albicans the most successful fungal pathogen of humans and, at the same time, identifying the stage of an infection at which certain virulence genes may play a role.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.