ArticleThe Journal of cell biology2000
A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 89 citations in OpenAlex.
- Molecular mechanism of contactin 2 homophilic interaction.Structure (London, England : 1993) · 2024Article
- Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of β-Catenin Signaling.International journal of molecular sciences · 2022Article
- To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly.Frontiers in neuroscience · 2022Review
- Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening.Development (Cambridge, England) · 2021Article
- Axon guidance at the spinal cord midline-A live imaging perspective.The Journal of comparative neurology · 2021Article
- Article
- Implication of Contactins in Demyelinating Pathologies.Life (Basel, Switzerland) · 2021Review
- Dorsal commissural axon guidance in the developing spinal cord.Current topics in developmental biology · 2021Review
- Article
- Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish.Mechanisms of development · 2018Article
- Human TUBB3 Mutations Disrupt Netrin Attractive Signaling.Neuroscience · 2018Article
- Contactin-2/TAG-1, active on the front line for three decades.Cell adhesion & migration · 2017Article
- Xenopus laevis neuronal cell adhesion molecule (nrcam): plasticity of a CAM in the developing nervous system.Development genes and evolution · 2017Article
- Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation.Frontiers in molecular neuroscience · 2017Review
- BACE1 activity regulates cell surface contactin-2 levels.Molecular neurodegeneration · 2014Article
- c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance.The Journal of biological chemistry · 2013Article
- Distinct cis regulatory elements govern the expression of TAG1 in embryonic sensory ganglia and spinal cord.PloS one · 2013Article
- RabGDI controls axonal midline crossing by regulating Robo1 surface expression.Neural development · 2012Article
- Rostral growth of commissural axons requires the cell adhesion molecule MDGA2.Neural development · 2011Article
- Contactins: structural aspects in relation to developmental functions in brain disease.Advances in protein chemistry and structural biology · 2011Review
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a guidance signal without promoting axon elongation. In an in vitro assay, commissural axons grew preferentially on stripes coated with a mixture of NrCAM and NgCAM. This preference was abolished in the presence of anti-axonin-1 antibodies without a decrease in neurite length. Consistent with these findings, commissural axons in vivo only fail to extend along the longitudinal axis when both NrCAM and NgCAM interactions, but not when axonin-1 and NrCAM or axonin-1 and NgCAM interactions, are perturbed. Thus, we conclude that axonin-1 is involved in guidance of commissural axons without promoting their growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.