ArticleThe Journal of cell biology2000
DNA dendrimers localize MyoD mRNA in presomitic tissues of the chick embryo.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- MyoD is required for the differentiation of Myo/Nog cell progenitors of myofibroblasts in explants of human lens tissue.Frontiers in ophthalmology · 2025Article
- Review
- Myo/Nog Cells Give Rise to Myofibroblasts During Epiretinal Membrane Formation in a Mouse Model of Proliferative Vitreoretinopathy.Investigative ophthalmology & visual science · 2023Article
- Acute Response and Neuroprotective Role of Myo/Nog Cells Assessed in a Rat Model of Focal Brain Injury.Frontiers in neuroscience · 2021Article
- Article
- Myo/Nog cells are nonprofessional phagocytes.PloS one · 2020Article
- Article
- Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgery.Experimental eye research · 2018Article
- Article
- Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens.PloS one · 2014Article
- Myo/Nog cells in normal, wounded and tumor-bearing skin.Experimental dermatology · 2012Article
- Myo/Nog cell regulation of bone morphogenetic protein signaling in the blastocyst is essential for normal morphogenesis and striated muscle lineage specification.Developmental biology · 2011Article
- Unique precursors for the mesenchymal cells involved in injury response and fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Noggin producing, MyoD-positive cells are crucial for eye development.Developmental biology · 2009Article
- Tracking and ablating subpopulations of epiblast cells in the chick embryo.Biological procedures online · 2008Article
- Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage.The Journal of cell biology · 2007Article
- Muscle development in Ciona intestinalis requires the b-HLH myogenic regulatory factor gene Ci-MRF.Developmental biology · 2007Article
- MyoD-positive epiblast cells regulate skeletal muscle differentiation in the embryo.The Journal of cell biology · 2006Article
- Epiblast cells that express MyoD recruit pluripotent cells to the skeletal muscle lineage.The Journal of cell biology · 2004Article
- MyoD-positive myoblasts are present in mature fetal organs lacking skeletal muscle.The Journal of cell biology · 2001Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
MyoD expression is thought to be induced in somites in response to factors released by surrounding tissues; however, reverse transcription-PCR and cell culture analyses indicate that myogenic cells are present in the embryo before somite formation. Fluorescently labeled DNA dendrimers were used to identify MyoD expressing cells in presomitic tissues in vivo. Subpopulations of MyoD positive cells were found in the segmental plate, epiblast, mesoderm, and hypoblast. Directly after laying, the epiblast of the two layered embryo contained approximately 20 MyoD positive cells. These results demonstrate that dendrimers are precise and sensitive reagents for localizing low levels of mRNA in tissue sections and whole embryos, and that cells with myogenic potential are present in the embryo before the initiation of gastrulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.