ArticleThe Journal of physiology2000
Ion channel sequestration in central nervous system axons.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed.
- Memristor-Based Spiking Neuromorphic Systems Toward Brain-Inspired Perception and Computing.Nanomaterials (Basel, Switzerland) · 2025Review
- Culturing Primary Cortical Neurons for Live-Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Voltage sensors of a NaNature communications · 2023Article
- Resilience of compound action potential peaks to high-frequency firing in the mouse optic nerve.Physiological reports · 2023Article
- Changing the firing threshold for normal optic nerve axons by the application of infra-red laser light.Scientific reports · 2021Article
- Article
- Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory.Experimental neurology · 2018Article
- Voltage-Activated Ion Channels in Non-excitable Cells-A Viewpoint Regarding Their Physiological Justification.Frontiers in physiology · 2018Article
- Axonal domain disorganization in Caspr1 and Caspr2 mutant myelinated axons affects neuromuscular junction integrity, leading to muscle atrophy.Journal of neuroscience research · 2017Article
- Predictions of the Contribution of HCN Half-Maximal Activation Potential Heterogeneity to Variability in Intrinsic Adaptation of Spiral Ganglion Neurons.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons.Frontiers in cellular neuroscience · 2017Article
- KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: support for electrically active myelin in mammalian saltatory conduction.Journal of neurophysiology · 2016Article
- Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression.Scientific reports · 2016Article
- Temporal Considerations for Stimulating Spiral Ganglion Neurons with Cochlear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2016Review
- Minimizing the caliber of myelinated axons by means of nodal constrictions.Journal of neurophysiology · 2015Article
- Ischemic tolerance in pre-myelinated white matter: the role of astrocyte glycogen in brain pathology.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Combination of electroacupuncture and grafted mesenchymal stem cells overexpressing TrkC improves remyelination and function in demyelinated spinal cord of rats.Scientific reports · 2015Article
- Myelin damage and repair in pathologic CNS: challenges and prospects.Frontiers in molecular neuroscience · 2015Review
- Aging-related changes of optic nerve of Wistar albino rats.Age (Dordrecht, Netherlands) · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Na+ and K+ channel localization and clustering are essential for proper electrical signal generation and transmission in CNS myelinated nerve fibres. In particular, Na+ channels are clustered at high density at nodes of Ranvier, and Shaker-type K+ channels are sequestered in juxtaparanodal zones, just beyond the paranodal axoglial junctions. The mechanisms of channel localization at nodes of Ranvier in the CNS during development in both normal and hypomyelinating mutant animals are discussed and reviewed. As myelination proceeds, Na+ channels are initially found in broad zones within gaps between neighbouring oligodendroglial processes, and then are condensed into focal clusters. This process appears to depend on the formation of axoglial junctions. K+ channels are first detected in juxtaparanodal zones, and in mutant mice lacking normal axoglial junctions, these channels fail to cluster. In these mice, despite the presence of numerous oligodendrocytes, Na+ channel clusters are rare, and when present, are highly irregular. A number of molecules have recently been described that are candidates for a role in the neuron-glial interactions driving ion channel clustering. This paper reviews the cellular and molecular events responsible for formation of the mature node of Ranvier in the CNS.
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Registered trials
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