ArticleThe EMBO journal2000
Telomere maintenance and length regulation in Trypanosoma brucei.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Leishmania mexicana telomeres at high resolution: Ku80, TERT, and alternative lengthening mechanisms.BMC genomics · 2025Article
- Article
- In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei.Nucleic acids research · 2021Article
- Diverse telomeres in trypanosomatids.Parasitology · 2021Article
- VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.Cellular microbiology · 2013Review
- DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes.PLoS pathogens · 2013Article
- Telomere components as potential therapeutic targets for treating microbial pathogen infections.Frontiers in oncology · 2012Article
- Telomere length in Trypanosoma brucei.Experimental parasitology · 2008Article
- Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest.Nucleic acids research · 2007Article
- Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei.Eukaryotic cell · 2006Article
- Telomerase-independent stabilization of short telomeres in Trypanosoma brucei.Molecular and cellular biology · 2006Article
- Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres.EMBO reports · 2006Article
- Trypanosome telomeres are protected by a homologue of mammalian TRF2.Molecular and cellular biology · 2005Article
- Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature.Genome research · 2005Article
- The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Review
- Telomere structure and shortening in telomerase-deficient Trypanosoma brucei.Nucleic acids research · 2005Article
- Biochemical properties of Trypanosoma cruzi telomerase.Nucleic acids research · 2004Article
- Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transcription of telomere proximal variant surface glycoprotein genes is mono-allelic in bloodstream-form Trypanosoma brucei. The terminal DNA sequence at these telomeres consists of tandem T(2)AG(3) repeats, which increase in length by approximately 8 bp per cell division balanced by occasional loss of large numbers of repeats. Here we have used targeted chromosome fragmentation to investigate the sequence requirements for telomere formation in T. brucei. Telomere formation is most efficient on tandem T(2)AG(3) repeats, but can also occur on specific templates found within 'random' sequence substrates and on G-rich motifs proximal to a double-strand break. Newly formed telomeres are extended faster than other native telomeres, but as the telomere becomes longer the rate of extension declines. Telomere length regulation in T.brucei is discussed in the context of recent results from other cell types.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.