ArticleThe EMBO journal2000
Structural and functional conservation at the boundaries of the chicken beta-globin domain.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 147 citations in OpenAlex.
- Chromatin insulators in gene regulation and 3D genome organization.Biochemical Society transactions · 2025Review
- Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia.Cell reports · 2023Article
- Transcriptional enhancers and their communication with gene promoters.Cellular and molecular life sciences : CMLS · 2021Review
- Setting boundaries for genome-wide heterochromatic DNA deletions through flanking inverted repeats in Tetrahymena thermophila.Nucleic acids research · 2019Article
- Engineering Globin Gene Expression.Molecular therapy. Methods & clinical development · 2019Review
- CTCF and cellular heterogeneity.Cell & bioscience · 2019Review
- Evolution of hemoglobin loci and their regulatory elements.Blood cells, molecules & diseases · 2018Review
- The chicken erythrocyte epigenome.Epigenetics & chromatin · 2016Article
- A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation.Nature communications · 2015Article
- Deletion of an X-inactivation boundary disrupts adjacent gene silencing.PLoS genetics · 2013Article
- Article
- Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages.Epigenetics & chromatin · 2012Article
- Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation.The Journal of biological chemistry · 2012Article
- Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression.Gene expression · 2012Article
- Using ΦC31 integrase to mediate insertion of DNA in Xenopus embryos.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Article
- Functional mimicry of the acetylated C-terminal tail of p53 by a SUMO-1 acetylated domain, SAD.Journal of cellular physiology · 2010Article
- High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene.Biochemistry · 2010Article
- Inactive X chromosome-specific histone H3 modifications and CpG hypomethylation flank a chromatin boundary between an X-inactivated and an escape gene.Nucleic acids research · 2009Article
- Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.The Journal of experimental medicine · 2009Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
We show that the 3' boundary of the chicken beta-globin locus bears striking structural similarities to the 5' boundary. In erythroid cells a clear transition in DNase I sensitivity of chromatin at the 3' end of the locus is observed, the location of this transition is marked by a constitutive DNase I hypersensitive site (HS), and DNA spanning this site has the enhancer-blocking capacity of an insulator. This HS contains a binding site for the transcription factor CTCF. As in the case of the 5' insulator, the CTCF site is both necessary and sufficient for the enhancer-blocking activity of the 3' boundary. The position of this insulator is consistent with our proposal that it may function to maintain the distinct regulatory programs of the globin genes and their closely appended 3' neighbor, an odorant receptor gene. We conclude that both boundaries of the chicken beta-globin domain are capable of playing functionally similar roles and that the same protein is a necessary component of the molecular mechanism through which these boundaries are defined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.