ArticleOccupational and environmental medicine2000
Detection of specific antibodies to pigeon serum and bloom antigens by enzyme linked immunosorbent assay in pigeon breeder's disease.
Article in Occupational and environmental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Diagnosis of Hypersensitivity Pneumonitis in Adults. An Official ATS/JRS/ALAT Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2020Guideline
- House dust protein level of pigeon drooping and feather in environmental bird exposure-related hypersensitivity pneumonitis "A pilot study".Lung India : official organ of Indian Chest Society · 2025Article
- Longitudinal changes in serum immunoglobulin G testing in patients with fibrotic avian hypersensitivity pneumonitis.BMC pulmonary medicine · 2024Article
- Sensitization to avian and fungal proteins in different work environments.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Immunopathological Mechanisms of Bird-Related Hypersensitivity Pneumonitis.International journal of molecular sciences · 2023Article
- A rapid test for the environmental detection of pigeon antigen.The Science of the total environment · 2021Article
- Barriers to antigen detection and avoidance in chronic hypersensitivity pneumonitis in the United States.Respiratory research · 2021Article
- Exposure Assessment Tools for Hypersensitivity Pneumonitis. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2020Article
- Review
- Diagnostic accuracy of specific IgG antibodies for bird fancier's lung: a systematic review and meta-analysis.Annals of translational medicine · 2019Article
- Identification of Diagnostic Criteria for Chronic Hypersensitivity Pneumonitis: An International Modified Delphi Survey.American journal of respiratory and critical care medicine · 2018Article
- Fibrotic Hypersensitivity Pneumonitis: Key Issues in Diagnosis and Management.Journal of clinical medicine · 2017Review
- Hypersensitivity pneumonitis: a complex lung disease.Clinical and molecular allergy : CMA · 2017Review
- Inhalation challenge in the differential diagnosis of usual interstitial pneumonia.European respiratory review : an official journal of the European Respiratory Society · 2015Article
- Hypersensitivity pneumonitis in children: clinical features, diagnosis, and treatment.Paediatric drugs · 2005Review
- Cockatiel-induced hypersensitivity pneumonitis.Environmental health perspectives · 2002Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPigeon breeder's disease is an extrinsic allergic alveolitis in the lungs of sensitised people, caused by hypersensitivity reactions to inhaled pigeon antigens. Antigens from different sources of the animal are used for diagnostic purposes, with serum being the most widely used. Bloom is rarely used; very little is known of its antigenicity and diagnostic performance, particularly when used with the enzyme linked immunosorbent assay (ELISA) method, which is the most popular test as it permits measurement of the antibody response.
methodsTo (a) standardise an ELISA for the measurement of specific IgG against pigeon serum and pigeon bloom extract; (b) to establish reference values for specific IgG in 73 non-exposed controls, (c) to show the presence of specific IgG against pigeon serum and bloom in serum samples of 17 patients with bird fancier's lung and 11 asymptomatic fanciers, and (d) to study the similarity of the two antigen sources by cross reactivity experiments.
resultsReference values of specific IgG were defined with the 97.5 percentile (367.9 U/ml for pigeon serum and 953.7 U/ml for pigeon bloom extract). Of symptomatic patients 100% had values higher than the cut off for both antigens. In asymptomatic fanciers values were higher than the cut off for pigeon serum in 45% and bloom extract in 54%. Cross reactivity experiments showed that the two antigens differed in antigenic content although some components may be common to both.
conclusionThe ELISA methods used proved to be useful tools for evaluating specific IgG antibody responses against both antigens. The diagnostic performance of both ELISA methods performed with these antigen sources was similar, showing very high sensitivity but moderate specificity. Although some antigenic similarity was found between pigeon serum and bloom extract, cross reactivity studies showed that various antigens seemed to be specific to the bloom extract. However, the antigens responsible for pigeon breeder's disease seem to be present in both antigenic sources.
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