ArticlePlant molecular biology2000
Tobacco TGA factors differ with respect to interaction with NPR1, activation potential and DNA-binding properties.
Article in Plant molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 109 citations in OpenAlex.
- Article
- TGA transcription factors-Structural characteristics as basis for functional variability.Frontiers in plant science · 2022Review
- Transcriptome analysis reveals pathogenesis-related gene 1 pathway against salicylic acid treatment in grapevine (Frontiers in genetics · 2022Article
- Heterologous Expression of theFrontiers in plant science · 2020Article
- The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) and Related Family: Mechanistic Insights in Plant Disease Resistance.Frontiers in plant science · 2019Review
- Integration of the Pokeweed miRNA and mRNA Transcriptomes Reveals Targeting of Jasmonic Acid-Responsive Genes.Frontiers in plant science · 2018Article
- Arabidopsis WRKY50 and TGA Transcription Factors Synergistically Activate Expression ofFrontiers in plant science · 2018Article
- A tandem affinity purification tag of TGA2 for isolation of interacting proteins in Arabidopsis thaliana.Plant signaling & behavior · 2014Article
- Article
- The NPR1 ortholog PhaNPR1 is required for the induction of PhaPR1 in Phalaenopsis aphrodite.Botanical studies · 2013Article
- NONEXPRESSOR OF PATHOGENESIS-RELATED PROTEINS1 (NPR1) and some NPR1-related proteins are sensitive to salicylic acid.Molecular plant pathology · 2011Article
- Tobacco Transcription Factor NtWRKY12 Interacts with TGA2.2 in vitro and in vivo.Frontiers in plant science · 2011Article
- Dissection of salicylic acid-mediated defense signaling networks.Plant signaling & behavior · 2009Review
- The Arabidopsis GRAS protein SCL14 interacts with class II TGA transcription factors and is essential for the activation of stress-inducible promoters.The Plant cell · 2008Article
- The role of bZIP transcription factors in green plant evolution: adaptive features emerging from four founder genes.PloS one · 2008Article
- Pathogen-induced Arabidopsis WRKY7 is a transcriptional repressor and enhances plant susceptibility to Pseudomonas syringae.Plant physiology · 2006Article
- Chromatin immunoprecipitation analysis of the tobacco PR-1a- and the truncated CaMV 35S promoter reveals differences in salicylic acid-dependent TGA factor binding and histone acetylation.Plant molecular biology · 2006Article
- Identification of NPR1-dependent and independent genes early induced by salicylic acid treatment in Arabidopsis.Plant molecular biology · 2005Article
- Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis.The Plant cell · 2005Article
- Salicylic acid-inducible Arabidopsis CK2-like activity phosphorylates TGA2.Plant molecular biology · 2005Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In higher plants, as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Originally found in viral and T-DNA promoters, they are also functional elements of plant promoters activated during the defence response against pathogens. Tobacco bZIP transcription factor TGA1a was the first recombinant protein shown to bind to as-1. cDNAs for two novel tobacco as-1-binding bZIP proteins (TGA2.1 and TGA2.2) were isolated. Revealing a high degree of amino acid identity in the bZIP domain (89%) and the C-terminus (79%), the two TGA2 factors differ remarkably with respect to the length of the N-terminus (170 amino acids in TGA2.1 versus 43 amino acids in TGA2.2). TGA2.1 and TGA2.2, but not TGA1a, interacted with ankyrin repeat protein NPR1, a central activator of the plant defence response. In contrast, TGA2.1 and TGA1a, but not TGA2.2, functioned as transcriptional activators in yeast. Apart from conferring transcriptional activation, the N-terminal domain of TGA2.1 led to reduced in vitro as-1-binding activity and almost completely abolished binding to one half site of this bifunctional element. When being part of a heterodimer with TGA2.2, TGA2.1 was efficiently recruited to a single half site, though double occupancy of the element was still preferred. In contrast, TGA1a preferred to bind to only one palindrome, a feature that was also maintained in heterodimers between TGA1a and TGA2.1 or TGA2.2.
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